Ephrin

spinqualitylabelsall models Structure of glycosylated human ephrin-A5 receptor-binding domain (green) complex with ephrin type A receptor 2 (cyan) (PDB code 3mx0). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Ephrins (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation . See also Ephrin receptor, Eph/ephrin signaling pathway, Ephrin Type-A Receptor. Ephrin-A3 has a role in forming precise tonotropy in the auditory brainstem to ensure accurate sound discrimination. Ephrin-A5 is required for the proper guidance and mapping of retinal axons in the mammalian midbrain. Ephrin-B1 has a role in palatal shelf outgrowth. Ephrin-B2 is a regulator of VEGFR signalling and thus controls angiogenic growth. Ephrin-B3 plays a key role at the midline to regulate axonal crossing. Disease Eph-A5 is implicated in spinal cord injury. Eph-A1 is implicated in myocardial injury and renal reperfusion injury. Structural highlights Ephrin-A5 receptor-binding domain complex with ephrin type A receptor 2 (PDB code 3mx0).

3D structures of ephrin

Updated on 18-June-2024

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• Ephrin-A1
  • Ephrin receptor, Eph/ephrin signaling pathway, Ephrin Type-A Receptor – hEph receptor-binding domain + Eph type A receptor 2
    
  • 3mx0 – hEph ectodomain
    
• Ephrin-A2
  • 2wo3 – hEph receptor-binding domain + Eph type A receptor 4
    
• Ephrin-A3
  • 3dzq – hEph kinase domain + inhibitor
    
• Ephrin-A5
  • 2x11, 3mx0 – hEph receptor-binding domain + Eph type A receptor 2 - human
    
  • 4bk5, 4bka, 4m4r – hEph receptor-binding domain + Eph type A receptor 4
    
  • 4l0p – hEph receptor-binding domain + Eph type A receptor 3
    
  • 1shx – mEph receptor-binding domain – mouse
    
  • 1shw – mEph residues 88-225 + Eph type B receptor 2
    
• Ephrin-B1
  • 6thg – hEph extracellular domain 27-170 + glycoprotein
    
  • 6p7s – mEph extracellular domain + glycoprotein
    
• Ephrin-B2
  • 2i85 – hEph residues 1-142 – NMR
    
  • 2wo2, 3gxu – hEph extracellular domain + Eph type A receptor 4
    
  • 4uf7, 6pdl – hEph extracellular domain + glycoprotein
    
  • 2vsk, 2vsm – hEph extracellular domain + virus hemagglutinin neuraminidase
    
  • 1iko, 7s7k – mEph ectodomain
    
  • 1kgy – mEph extracellular domain + Eph type B receptor 2
    
  • 2hle – mEph extracellular domain + Eph type B receptor 4
    
  • 6p7y – mEph extracellular domain + glycoprotein
    
• Ephrin-B3
  • 4bkf – hEph receptor-binding domain + Eph type A receptor 4
    
  • 3d12 – mEph receptor-binding domain + virus hemagglutinin neuraminidase
    

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