Epidermal growth factor

spinqualitylabelsall models Dimer of the monomeric human epidermal growth factor (PDB code 1jl9) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Epidermal growth factor (EGF) plays a role in cell growth. It binds to its receptor (EGFR). EGF is regulated by iodine. EGF is part of a family of proteins with similar structure and activity. Some details on EGF exon in EGF1 on Gla domain in Gla domain Pre-prozymogen. Relevance EGFR-dependent cancers are deprived of stimulus by EGF by raising antibodies against EGF via vaccination. Structural highlights All EGF family proteins contain a conserved amino acid sequence which includes 3 disulfide bonds (PDB code 1jl9).

3D structures of epidermal growth factor

Updated on 01-June-2025

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• EGF domains: extracellular 971-1023
  • EGFR – hEGF
    
  • EGF1 – hEGF - NMR
    
  • Gla domain, Pre-prozymogen – hEGF/transforming growth factor alpha - NMR
    
  • 1jl9, 3njp – hEGF 1-53 + EGFR
    
  • 1nql – hEGF extracellular domain + EGFR
    
  • 7syd, 7sye, 7sz0, 7sz1, 8hgs - hEGF extracellular domain + EGFR – Cryo EM
    
  • 8hgo – hEGF extracellular domain + HER2 + EGFR – Cryo EM
    
  • 7om4 - hEGF extracellular domain + EGFR + nanobody
    
  • 1egf, 1epg, 1eph, 1epi, 1epj, 3egf – mEGF – mouse – NMR
    
  • 1a3p – mEGF (mutant) – NMR
    
• Heparin-binding EGF-like growth factor
  • 1xdt – hHB-EGF extracellular domain + diphtheria toxin
• EGF-like Cripto protein
  • 2j5h – mCR-EGF residues 96-134 - NMR

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