Forkhead box protein

spinqualitylabelsall models Human FoxO1 DNA-binding domain complex with DNA, Ca+2 and chloride ions, 3co6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Forkhead box proteins (FOX) are transcription factors involved in regulation of gene expression.. FOXO1 activation contributes to glucocorticoid-induced beta cell death. FOXO3 negatively regulates autophagy in human cancer cells. FOXP1 is a key reppressor of immune signaling in the CNS. FOXP2 increases synaptic plasticity and dendrite connectivity. See FOXP2 and Foxp2 bound specifically to DNA FOXP3 drives T cell regulatory function. See Forkhead Box Protein 3 and FOXP3 mutation- IPEX syndrome FOXK1 is a tumor suppressor in facilitating angiogenesis and metastasis in breast cancer. FOXM1 high expression is correlated with poor prognosis of patients with osteosarcoma. See Forkhead box protein M1. FOXN1 mutations result in phenotype of hairlessness and athymia resulting in severely compromised immune system. FOXN3 is bispecific and recognizes two DNA motifs. See also Transcription and RNA Processing Glucocorticoids Steroid Hormones and their receptors. Neurodevelopmental Disorders. Disease FOX mutations are implicated in congenital heart disease. FOXC2 counteracts obesity, hypertriglyceridemia and diet-induced insulin resistance. Truncated FOXC2 causes multiple lymphedema syndrome. Structural highlights FOX contain a DNA-binding motif (DBD) of 80-100 amino acids having a winged-helix shape. Human FoxO1 DNA-binding domain with DNA, Ca+2 and Cl- ions. Ca coordination site. Water molecules shown as red spheres. Cl coordination site. 3D structures of FOX FOX 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David Canner