Factor VIII

spinqualitylabelsall models Glycosylated human Factor VIII. Residues 19-760 (cyan), 1582-2351 (magenta) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code 2r7e) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Factor VIII (FVIII) is a blood clotting factor. FVIII is a cofactor for factor IXa . See also Factor VIII (Hebrew). First Ca coordination site. Second Ca coordination site. First Cu coordination site. Second Cu coordination site (PDB code 2r7e). Disease Defects in the protein result in hemophilia A. Relevance Factor VIII is given to hemophiliacs in order to restore homestasis.

3D Structures of Factor VIII

Updated on 27-February-2023

factor IXa, Factor VIII (Hebrew), 2r7e, hemophilia, 6mf2 – hFVIII 19-760+1582-2351 – human
6mf0 – h/pFVIII
3hnb, 3hny, 3hob, 4pt6 – hFVIII light chain C2 domain 2189-2347
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
7k66, 7kbt – h/pFVIII + antibody
4xzu - hFVIII light chain C2 domain + monoclonal Fab
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
3j2s - hFVIII light chain 1710-2356
5k8d - hFVIII heavy chain + light chain residues 104-329
7kwo – hFVIII + VWF-XTEN
4mo3 - pFVIII light chain C2 domain – pig
7s0p - pFVIII light chain C2 domain + phosphatidylserine
4ki5 - mFVIII light chain C2 domain + monoclonal Fab – mouse

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Alexander Berchansky, Michal Harel