Factor XIII

spinqualitylabelsall models Human Factor XIII dimer (PDB entry 1ggt) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Factor XIII (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide. Disease FXIII deficiency causes internal bleeding.

3D Structures of Factor XIII

Updated on 08-June-2025

1ggt – hFXIII - human
8cmt, 8cmu - hFXIII – Cryo EM
1ex0 – hFXIII zymogen (mutant)
1fie – hFXIII subunit A
1f13 - hFXIII zymogen subunit A dimer
4kty - hFXIII subunit A + peptide-like ligand
5mhl, 5mhm, 5mhn, 5mho - hFXIII subunit A (mutant) + peptide inhibitor
1ggy, 1qrk, 1ggu, 1evu – hFXIII + ion
1de7 – hFXIII activation peptide + α-thrombin

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Alexander Berchansky, Michal Harel