Factor inhibiting HIF

spinqualitylabelsall models Dimeric factor inhibiting HIF complex with oxogluterate derivative (PDB code 1mzf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D For details on Factor inhibiting HIF or Hypoxia-inducible factor 1-alpha inhibitor see Molecular Playground/FIH. HIF is hypoxia-inducible factor - transcription factors that respond to hypoxia, i.e., decrease in oxygen. Dimeric factor inhibiting HIF with oxogluterate derivative. Fe/2-oxogluterate binding site (PDB code 1mzf).

3D Structures of factor inhibiting HIF

Updated on 05-June-2025

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• FIH1α
  • Molecular Playground/FIH, 1mzf, 1iz3 – hFIH1α – human
• FIH1α complex with small molecule
  • 1yci, 3od4, 2yc0, 2yde, 5op6, 5op8, 5opc, 8ihz, 8ii0, 8k71, 8k72, 8k73, 9i4h – hFIH1α + inhibitor
    
  • 2w0x - hFIH1α + pyridine derivative
    
  • 2cgn – hFIH1α + succinate
    
  • 2cgo – hFIH1α + fumarate
    
  • 1mzf, 2wa3, 2wa4, 2yc0, 2yde, 4z2w, 5jwk, 7a1j, 7a1k, 7a1l, 7a1m – hFIH1α + oxoglutarate derivative
    
  • 5jwk, 5jwl - hFIH1α (mutant) + ketoglutarate
    
  • 3kcx, 3kcy, 3od4, 4bio, 9jtx - hFIH1α + quinol derivative
    
  • 4ai8 - hFIH1α + daminozide
    
  • 4z1v - hFIH1α + oxalylglycine + NO
    
  • 9fsn, 9iif - hFIH1α + anemia drug
    
• FIH1α complex with polypeptide
  • 1h2k, 1h2l, 1h2m – hFIH1α + HIF transactivation domain peptide
    
  • 2ilm, 3d8c, 5jwp - hFIH1α (mutant) + HIF peptide + α-ketoglutarate
    
  • 3p3n, 3p3p - hFIH1α + Notch 1 peptide
    
  • 2xum - hFIH1α (mutant) + Asp-substrate peptide + oxoglutarate derivative
    
  • 2y0i - hFIH1α + tankyrase 2 peptide
    
  • 3hqr, 3hqu - hFIH 1α C terminal + EGL nine homolog
    
  • 1lqb, 1lm8 - hFIH 1α residues 549-582 + elongin B + elongin C + PVHL
    
  • 1l3e - hFIH 1α C terminal + P300 Cys/His-rich domain – NMR
    
  • 1l8c - hFIH 1α C terminal + CREB-binding protein zinc finger
    
  • 4h6j - hFIH 1α PAS B domain (mutant) + aryl hydrocarbon nuclear translocator
    
  • 4b7e, 4b7k, 4jaa, 4nr1, 7a1q - hFIH1α + consensus ankyrin repeat peptide
    
  • 7a1n, 7a1o, 7a1p, 7a1s - hFIH1α + consensus ankyrin repeat peptide + oxoglutarate derivative
    
  • 6h9j, 6ha6 - hFIH1α + TRPV3 peptide + oxalylglycine
    
  • 6hc8 - hFIH1α + TRPA1 peptide + oxalylglycine
    
  • 6hl6 - hFIH1α + ASPP peptide + oxalylglycine
    
  • 6hl5 - hFIH1α + ASPP1 peptide + oxalylglycine
    
  • 6hkp - hFIH1α + ASPP2 peptide + oxalylglycine
    
  • 6ruj - hFIH1α + ankyrin repeat + oxalylglycine
    
• FIH2α
  • 2a24, 3f1n, 3f1o, 3f1p, 3h7w - hFIH 2α PAS domain + hFIH 1β PAS domain
    
  • 3h82 - hFIH 2α PAS domain (mutant) + hFIH 1β PAS domain (mutant)
• FIH1β
  • 2b02, 1x0o - hFIH 1β PAS domain
    
  • 2hv1, 2k7s- hFIH 1β PAS domain - NMR
    

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