File:Homocysteine metabolic pathway.png
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Beskrivning
Homocysteine metabolic pathway. Homocysteine sits at the intersection of the remethylation and transsulfuration pathways. In the remethylation pathway, THF is converted to N5,N10-methylene tetrahydrofolate and then to MTHF by methylenetetrahydrofolate reductase (Mthfr). The methyl group is donated to Hcy and in the presence of methionine synthase (Mtr), and B12 is converted to methionine. Methionine is used in many methyl transfer reactions. When the diet is replete with methionine, Hcy is converted, via the transsulfuration pathway, to cystathionine by cystathionine β-synthase (Cbs) and then converted to cysteine via the action of cystathionase (Cth, Cse) in the presence of B6. Cysteine is converted to several beneficial downstream products.
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Cui X, Navneet S, Wang J, Roon P, Chen W, Xian M, Smith SB. Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice. Invest Ophthalmol Vis Sci. 2017 Apr;58(4):1954-1963. doi: 10.1167/iovs.16-21247. PubMed PMID: 28384716; PubMed Central PMCID: PMC5381329.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 19:48, 28 April 2019 | | 998 × 911 (296 KB) | Jan Hamalcik (talk | contribs) | Homocysteine metabolic pathway. Homocysteine sits at the intersection of the remethylation and transsulfuration pathways. In the remethylation pathway, THF is converted to N5,N10-methylene tetrahydrofolate and then to MTHF by methylenetetrahydrofolate red |
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