File:PCSK9 domains2.png
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Schematic representation of PCSK9 gene (A) and protein (B). A: exons of PCSK9 gene are shown as coloured boxes. Each colour corresponds to a different domain of the protein. B: Representation of PCSK9 protein domains: signal sequence (SS, black), prodomain (red), catalytic domain (blue) and Cys, His rich C-terminal domain (green). The autocatalytic cleavage site at Gln152 is indicated with an arrow. Once the protein has been processed in the endoplasmic reticulum (ER), the prodomain remains bound to the catalytic domain. The catalytic domain is linked to the C-terminal domain through a 18 amino acids hinge region (HR). Numbers above each domain indicate the amino acid number of the protein sequence.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 17:22, 30 December 2017 | | 1,280 × 720 (84 KB) | Rafael Romero Becerra (talk | contribs) | Schematic representation of PCSK9 gene (A) and protein (B). A: exons of PCSK9 gene are shown as coloured boxes. Each colour corresponds to a different domain of the protein. B: Representation of PCSK9 protein domains: signal sequence (SS, black), prodomai |
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