File:Positions of the mutations in PR variants used for structural studies.jpg
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Summary
Positions of the mutations in PR variants used for structural studies. (A) Each monomer of PR is used to depict the mutations in the PRDRV1 and PRDRV5 variants in red and blue, respectively. Mutated residues are represented with their Cα atoms (spheres) and their transparent solvent-accessible surfaces. Active-site aspartates are shown as sticks; darunavir bound to the active site is represented by sticks, and its solvent-accessible surface area is green. (B) Sequence alignment of PRDRV1 and PRDRV5 with the wild-type (WT) sequence. Primary mutations in residues interacting directly with darunavir are in boldface italics.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 18:27, 29 December 2012 | 652 × 625 (98 KB) | Angelika Wackerl (talk | contribs) | Positions of the mutations in PR variants used for structural studies. (A) Each monomer of PR is used to depict the mutations in the PRDRV1 and PRDRV5 variants in red and blue, respectively. Mutated residues are represented with their Cα atoms (spheres) |
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