Flagellar protein

spinqualitylabelsall models Flagellin major fragment of Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function The bacterial flagellum consists of a filament, a universal joint (hook), and a motor (basal body). Flagella (singular: flagellum) enable bacteria to swim towards sources of nutrition, and away from sources of toxins. Such directed motility is termed chemotaxis. Rapid swimming helps Bdellovibrio penetrate and parasitize their host bacteria, but flagella are not always essential for virulence. Flagella are important in responses to quorum sensing and biofilm formation. Flagella may also be involved in functions other than motility. FlgA is essential for P-ring formation in Salmonella and E. coli. FlgD is essential for hook assembly in Salmonella. FlgE is the subunit of the hook that connects the basal body and the filament. FlgG is a rod protein in Salmonella. FlgJ functions as a lytic beta-N-acetylglucosaminidase. FlgK and FlgL have a role in the smooth connectivity between the hook and the filament. FlhA serves as a docking platform for flagellar chaperones in complex with their filament-type substrates. FlhB is a component of the flagellar secretion system and has a role in protein export. FlhE acts as chaperone to regulate flow of proteins through the flagellar type III secretion system. FlhF is a signal recognition particle-like GTPase regulating flagellar number and polarity. FliD regulates filament assembly by chaperoning Flagellin proteins. It is the component of the cap at the tip of the external filament. FliG is a cytoplasmic protein which binds to the transmembranal FliF to form the cytoplasmic flagellar ring. FliH, FliI and FliJ make an ATPase complex which is part of the flagellar export apparatus. FliL is part of the motor stator in Helicobacter. FliM is involved in the clockwise rotation of the flagellar motor. FliN with FliM and FliG form the switch complex that functions in flagellar assembly, rotation and switcing. FliP, FliQ and FliR are part of the membrane-embedded flagellar export apparatus. FliS is a flagellin specific type III secretion system chaperone that facilitates the export of flagellin. FliT is a flagellin specific type III secretion system chaperone that facilitates the export of FliD. FliY is part of the B. subtilis switch complex. FlcpA and FcpB are flagellar coiling proteins of leptospira, . For further information, please see Flagellum at Wikipedia. The bacterial flagellum is made up of about 25 different proteins. There are only a few copies of some proteins, and tens of thousands of copies of the filament protein, FliC. The flagellum is made up of three major regions, as follows. Motor At the base of a bacterial flagellum is a reversible motor, also called the basal body. The source of energy driving the motor is an electromotive gradient of, in some bacteria, protons (hydrogen ions, H+) or, in other bacteria, sodium ions (Na+). The gradient has a higher concentration of ions outside the cell, and a lower concentration of ions inside the cell. Ions flow from outside to inside the bacterial cell, passing through the motor and driving its rotation by a mechanism which is poorly understood. For more details see Flagellar biosynthetic protein Filament (Propeller) The flagellar filament is a relatively rigid, helical rod, typically many times the length of the bacterial cell. Many motile bacteria, including Salmonella, have multiple flagella extending from each cell. Rotation of the filaments by the motor is what propels the cell. More... For more details see Flagellar proteins and Flagellar filament of bacteria. Hook (Universal Joint) The filament is attached to the motor with the flagellar hook, which is a molecular universal joint. The hook is flexible, allowing the angle between the filament and the bacterial cell surface to change over a wide range. However, the hook efficiently transmits torque from the motor to the filament, causing it to rotate. For details see Flagellar hook of bacteria Samatey/5 Assembly     Assembly of the bacterial flagellum. Credit: Protonic Nanomachine Project, used with permission of Keiichi Namba, Osaka University. During assembly of the flagellum, its protein components are transported through hollow cores of the basal body, hook and filament, assembling at the end of the nascent flagellum. The Namba Group has prepared a movie illustrating their understanding of the assembly process as of about 2004. 3D structures of flagellar protein Flagellar protein 3D structures Lists of Flagellar Structures These are automatically-generated lists of PDB codes. Special:Prefixindex/Category:Flagell includes categories beginning with Flagellar, Flagellin, Flagella, Flagellum. Special:Prefixindex/Category:Bacterial flagell Category:Chlamydomonas flagella Category:The bacterial flagellar motor Category:Putative flagellar motor switch protein flin and there are undoubtedly other flagellum-related Categories ... See Also Within Proteopedia: Flagellar filament of bacteria Flagellar hook of bacteria Fadel A. Samatey Group External Links Flagellum at Wikipedia Protonic Nanomachine Group, Osaka University MOVIES from the Protonic Nanomachine Project, Osaka University

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Eric Martz, Michal Harel, Fadel A. Samatey, Joel L. Sussman, Jaime Prilusky