Flavin reductase

spinqualitylabelsall models Human flavin reductase complex with biliverdin IXα and NADP (PDB code 1he2) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Flavin reductase (FR) catalyzes the NADPH-dependent reduction of a variety of flavins such as riboflavin, FAD, FMN, biliverdin, methemoglobin and pyrroloquinoline quinone. FR converts reduced riboflavin to riboflavin and bilirubin to biliverdin. FR is involved in heme catabolism . Relevance FR catalytic reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia. Bacterial FR are used to sensitize tumors to drugs. Structural insights The NADP containing active site can accommodate a variety of ligands because the binding is achieved mainly via hydrophobic interactions (Hydrophobic, Polar).

3D structures of flavin reductase

Updated on 06-July-2025

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• NADPH-dependent Flavin reductase or biliverdin IX beta reductase
  • 8ell, 8elm – hFR – human
  • 1hdo, 7er6, 9c18 - hFR + NADP
    
  • 6opl – hFR (mutant) + NADP
    
  • 1he2 - hFR + biliverdin IX α + NADP
    
  • 1he3 - hFR + mesobiliverdin IV α + NADP
    
  • 1he4 - hFR + FMN + NADP
    
  • 1he5 - hFR + lumichrome + NADP
    
  • 5ooh – hFR + NADP + erythrosine
    
  • 5oog – hFR + NADP + phloxine + cyanosine
    
  • 7er7, 7er8, 7er9, 7era, 7erb, 7erc, 7erd, 7ere – hFR + NADP + drug
    
  • 8k4k, 9c16, 9c17 – hFR + NADP + inhibitor
    
  • 3pft - FR (mutant) + FMN – Mycobacterium goodii
    
  • 5cho - FR + FAD – uncultured bacteria
    
  • 1qfj – FR – Escherichia coli
    
  • 1bkj – VhFR + FMN – Vibrio harveyi
    
  • 2bkj - VhFR + NAD + FMN
    
• NADH-dependent Flavin reductase
  • 1rz0 – GtFR + FAD – Geobacillus thermoglucosidasius
    
  • 1rz1 - GtFR + FAD + NAD
    
  • 5n6q - PpFR + FMN – Pseudomonas putida
    
  • 4uth - PpFR (mutant) + FMN
    
  • 5lnj, 5lni, 4uti, 4utj - PpFR (mutant) + FMN derivative + coumarin derivative
    
  • 2d36 - StFR + FMN – Sulfurisphaera tokodaii
    
  • 2d37 - StFR + FMN + NAD
    
  • 2d38 - StFR + FMN + NADP
    
  • 9fd4, 9fd5 - FR + FAD – Streptomyces albogriseolus
    
  • 8ct0 - FR + FAD + NAD – Kitasatospora aureofaciens
    

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