Furin

spinqualitylabelsall models Human furin complex with peptide inhibitor, Ca++ (green), Na+ (purple), citrulline, phenylacetaldehyde and aminoetyl-benzenecarboximiidamide (PDB 6eqv) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Furin or proprotein convertase furin or dibasic-processing enzyme or paired basic amino acid residue-cleaving enzyme or PACE is a member of the proprotein convertase family and promotes the proteoplytic maturation of proproteins. Furin cleaves precursor proteins at their paired basic amino acid processing sites. Relevance High furin activity promotes the malignant phenotype of cancer cells in head and neck squamous cell carcinoma, breast cancer and . Furin has a role in atherosclerosis. The new coronavirus SARS-CoV19 genome sequence shows a furin-like cleavage site in the spike protein. This cleavage site has potential implications in the development of antivirals. See SARS-CoV-2 protein S priming by furin, an animation.

3D structures of furin

Updated on 07-July-2025

SARS-CoV-2 protein S priming by furin, 5jxi - hFur - human
4z2a - hFur (mutant)
4omc, 4omd, 4ryd, 5jxh, 5jxj, 6eqv, 6eqw, 6eqx, 6hlb, 6hld, 6hle, 6hza, 6hzb, 6hzc, 6hzd, 8b4x, 8oyh - hFur + peptide inhibitor
5mim, 6yd2, 6yd3, 6yd4, 6yd7, 7lcu, 7o1u, 7o1w, 7o1y, 7o20, 7o22, 7qxy, 7qxz, 7qy0, 7qy2, 8b4v, 8b4w - hFur + inhibitor
5jmo - hFur + antibody
1p8j - mFur + peptide inhibitor - mouse

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