Gal3-Gal80-Gal4

spinqualitylabelsall models Yeast Gal4 complex with DNA and Zn+2 ions (wheat) (PDB entry 1d66) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Gal3-Gal80-Gal4 proteins of yeast comprise a signal transducer that controls the galactose-inducible Gal4-mediated transcription activation of GAL regulon genes. Gal3 and Gal4 are regulators of the rapid induction of the galactose system. In the absence of galactose Gal80 binds to Gal4 and prohibits it from activating transcription. In the presence of galactose, Gal3 binds to Gal80 to prohibit its inhibition of Gal4. For Gal4 details see User:Amir Mitchell/Gal4 User: Wayne Decatur/Gal 4 Evans Gal4 DNA-protein interactions. The Gal4 protein consists of a dimer of identical subunits.

3D Structures of Gal3-Gal80-Gal4

Updated on 07-July-2025

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• Gal3
  • 3v5r – yGal3 – yeast
    
  • 3v2u – yGal3 + Gal80 + ATP + galactose
    
• Gal4
  • Evans Gal4 – yGal4 DNA-binding domain – yeast – NMR
    
  • DNA-protein interactions - yGal4 dimerization domain – NMR
    
  • 3coq - yGal4 DNA-binding and dimerization domains + DNA
    
  • 1d66 – yGal4 + DNA
  • 7uik, 7uio – yGal4 in mediator-PIC complex – Cryo EM
• Gal80
  • 2nvw – KlGal80 – Kluyveromyces lactis
    
  • 3e1k – KlGal80 + lactose regulatory protein Lac9 peptide
    
  • 3btu, 3btv – yGal80 (mutant)
    
  • 3bts – yGal80 + Gal4 peptide + NAD
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Ann Taylor, Wayne Decatur, Jaime Prilusky