Galactokinase

spinqualitylabelsall models Se-Met human GALK complex with galactopyranose, AMPPNP and Mg+2 ion (green) (PDB code 1wuu. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Galactokinase (GALK) is the enzyme which catalyzes the second step in the Leloir pathway which converts β-D-galactose to glucose 1-phosphate. GALK catalyzes the conversion of α-D-galactose to galactose 1-phosphate. Disease Hereditary GALK deficiency is called galactosemia. The symptoms are early onset of cataract and impairment of galactose (gal) metabolism.. Structural highlights The 3D structure of human GALK shows the sugar binding active site wedged between the N- and C-termini of the enzyme. The galactose forms numerous interactions with GALK termini residues and in particular forms hydrogen bonds with an Asp and Arg residues which are conserved in eukaryotic and prokaryotic GALK. Mg coordination site. AMPPNP binding site. Whole binding site. 3D structures of galactokinase Updated on 07-March-2023 6gr2 - hGALK + ADP + gal - human 7rcl, 7rcm - hGALK (mutant) + ADP + gal 1wuu - hGALK + Mg + AMPPNP + gal 6q3w, 6q8z - hGALK + pyrazine derivative + gal 6q91 - hGALK + benzamide derivative + gal 6q90, 6zgw - hGALK + pyridine derivative + gal 6q3x, 6zfh, 7s49 - hGALK + quinazoline derivative + gal 6zgv, 6zgx, 6zgz, 6zgy, 6zh0 - hGALK + pyrimidine derivative + gal 7s4c - hGALK (mutant) + pyrimidine derivative + gal 6qje - hGALK + imidazole derivative + gal 7ozx - hGALK + inhibitor + gal 2aj4 - GALK + Mg + AMPPNP + gal - yeast 1s4e - GALK + Mg + ADP + gal - Pyrococcus furiosus 2dej, 2dei - GALK + AMPPN derivative + gal - Pyrococcus horikoshii 1pie - GALK + gal - Lactococcus lactis 6tep - BiGALK + Mg + ADP - Bifidobacterium infantis 6ter, 6teq - BiGALK + gal derivative

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky