Galactoside O-acetyltransferase

spinqualitylabelsall models Galactoside O-acetyltransferase complex with acetyl-CoA (PDB code 1krr) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Galactoside O-acetyltransferase (GAT) assists cellular detoxification by acetylating the 6-hydroxyl group of nonmetabolizable pyranosides like galactosides, glucosides and lactosides and thus preventing their reentry into the cell. GAT gene is part of the lac operon. Structural highlights The structure of the complex of GAT with the cofactor acetyl-CoA shows that the latter binds to residues in a crevice between two subunits. Water molecule shown as red sphere. Acetyl-CoA is in a crevice between two subunits.

3D structures of galactoside O-acetyltransferase

Updated on 10-December-2018

1kqa, 1krr – EcGAT + Acetyl CoA – Escherichia coli
1kru, 1krv – EcGAT + Acetyl CoA + galactopyranose derivative
3ftt – SaGAT – Staphylococcus aureus
3v4e, 5u2k, 5v0z – SaGAT + Acetyl CoA
3vbi – BcGAT + Acetyl CoA + TDP derivative – Bacillus cereus
3vbn, 3vbp, 3vbk, 3vbl, 3vbm – BcGAT (mutant) + Acetyl CoA + TDP derivative
3vbj – BcGAT + butyryl CoA + TDP

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