Gelsolin

spinqualitylabelsall models Human gelsolin S4-S6 (gold) complex with actin (cyan), ATP and Ca+2 ion (green) (PDB entry 1h1v) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Gelsolin (GLS) is a protein regulator of actin assembly and disassembly. Binding of Ca+2 ion to GLS induces conformational change which enables it to bind actin. Structural highlights GLS contains 6 homologous domains S1 to S6. The human GLS domains span residues: 15-135, 136-248, 249-367, 394-513, 514-619 and 620-734. S4-S6 are shown. The binding site of Ca+2 ion includes Glu, Asp and 2 carbonyl oxygens. 3D Structures of gelsolin Gelsolin 3D structures

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