Gephyrin

spinqualitylabelsall models Rat gephyrin E domain (cyan) complex with glycine receptor peptides (magenta and pink), acetate and Ca+2 ion (green) (PDB code 4u91) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Gephyrin (Gep) is responsible for Mo cofactor biosynthesis and for postsynaptic clustering of glycine receptors and type A GABA receptors in the vertebrate CNS. Gep self-assembles to form scaffolds in the synapse. Relevance Abnormal accumulation of Gep are highly correlated with the neuropathologic diagnosis of Alzheimer Disease. Structural highlights Para-Phenyl crosslinked Glycine receptor beta subunit derived dimeric peptide interacts with several side chains of Gep. 1,1'-benzene-1,4-diylbis(1H-pyrrole-2,5-dione) crosslinking with peptides

3D structures of gephyrin

Updated on 12-March-2023

2fu3, 5erq, 4pd0 - rGeph E domain 318-736 - rat
2fts, 4pd1, 1t3e, 4u91 - rGeph E domain + glycine receptor peptide
6hso - rGeph E domain + glycine receptor peptide + ADP<br / 4tk1, 4tk2, 4tk3, 4tk4, 4u90 - rGeph E domain + GABA receptor peptide
6hsn - rGeph E domain + GABA receptor peptide + ADP
5ers - rGeph E domain + AMP
5ert, 5err - rGeph E domain + ADP
5eru - rGeph E domain + ADP + Mo + MoO4
5erv - rGeph E domain + ADP + W + WO4
6fgc - rGeph E domain + artesunate + ADP
6fgd - rGeph E domain + artemether + ADP
1ihc, 1jlj - rGeph N terminal
1eav - rGeph G domain 462-623 – Arabidopsis thaliana

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky