Glucocorticoid receptor

spinqualitylabelsall models Rat glucocorticoid receptor DNA-binding domain dimer complex with DNA and Zn+2 ions (grey) (PDB entry 3g6r) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Glucocorticoid receptor (GCR) is the nuclear receptor binding cortisol and glucocorticoids. GCR regulates genes involved in development, metabolism and immune response. GCR interacts with nuclear receptor coactivator 2 (NCOA2) which promotes DNA transcription by acylating histones. See also: Glucocorticoids Intracellular receptors Steroid Hormones and their receptors. Relevance The glucocorticoid-bound GCR can either up-regulate the expression of anti-inflammatory proteins (transactivation) or repress the expression of pro-inflammatory proteins (transrepression). Disease Budesonide is an agonist of GCR and is used as medication for asthma and inflammatory bowel diseases like chronic obstructive pulmonary disease. Structural highlights GCR contains 5 domains: N terminal regulatory domain; DNA-binding domain (DBD) residues 417-506; hinge region; ligand-binding domain (LBD) residues 521-777 and C terminal domain. Human glucocorticoid receptor ligand-binding domain bound to dexamethasone (1m2z). Glucocorticoid Receptor in complex with budesonide (5nfp). Budesonide binding site. Water molecule is shown as red sphere. Crystal Structure of mometasone furoate-bound glucocorticoid receptor ligand binding domain (4p6w). Mometasone furoate binding site. 3D structures of glucocorticoid receptor Glucocorticoid receptor 3D structures

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