Glutaminyl cyclase

spinqualitylabelsall models Structure of human glutaminyl cyclase complex with benzyimidazole and Zn+2 ion (PDB code 2afx). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Glutaminyl cyclase (QC) or glutaminyl-peptide cyclotransferase catalyzes the conversion of glutaminyl-peptide to 5-oxoprolyl-peptide and ammonia. Thus QC catalyzes the cyclization of an N-terminal glutamyl residue. Relevance The biological assembly of Human Glutaminyl cyclase is homohexamer. QC is considered as a marker of thyroid tumors. QC acts on the generation of N-terminal pyroglutamyl groups of peptide hormones and amyloid-related plaque-forming peptides. The latter contributes to Alzheimer disease. Alzheimer patients show increased expression of QC and QC inhibitors reduces the disease pathology and symptoms. Structural highlights The active site of QC contains a Zn+2 ion.

3D Structures of glutaminyl cyclase

Updated on 17-July-2025

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• Glutaminyl cyclase
  • 2afm, 2afo – hQC + Zn – human
    
  • 2afs, 2zed, 2zee, 2zef, 2zeg, 2zeh, 2zel, 2zem, 2zen, 2zeo, 2zep, 3pbe, 4yu9, 7cp0 – hQC (mutant) + Zn
    
  • 9fxh, 9fxv – hQC (mutant) + Co
    
  • 9fxg – hQC (mutant)
    
  • 3pb4, 3pb6 – hQC catalytic domain + Zn
    
  • 3si1 – mQC + Zn – mouse
    
  • 4f9u, 4fai, 4fwu – DmQC – Drosophila melanogaster
    
  • 4f9v, 4fbe – DmQC (mutant)
    
  • 2faw – QC – papaya
    
  • 3mbr – QC – Xanthomonas campestris
    
  • 3nol, 3nom – QC – Zymomonas mobilis
    
  • 3nok – QC – Myxococcus xanthus
    
  • 4mhn, 4mhp, 7d1n, 7d1p, 7d1y, 7d21, 7d23, 7d2b, 7d2d, 7d2i, 7d2j – IsQC catalytic domain – Ixodes scapularis
    
  • 7d1h – IsQC catalytic domain (mutant)
    
  • 7d17 – QC – Macrostormum lignano
    
  • 6qql, 7cje, 7cjg – QC – Porphyromonas gingivalis
    
  • 7d18 – QC – Acidobacteriales bacterium
    
  • 7d1b – QC – Fimbrilglobus ruber
    
  • 6qro – QC – Tannerella forsythia
    
  • 8vpl, 8vpm – QC + Zn – Aspergillus flavus
    
• Glutaminyl cyclase complex
  • 2afu – hQC + glutamine t-butyl ester
    
  • 2afw – hQC + N-acetylhistamine
    
  • 2afx, 3si0, 2afz, 3pb9, 7cm0, 7d8e, 8hy3, 8xfv, 8xga, 8xgb, 8xgt, 8xgy, 9isd, 9ivv, 9kmb – hQC catalytic domain + imidazole derivative + Zn
    
  • 9fxi – hQC (mutant) + inhibitor + Co
    
  • 3pb7, 3pb8, 3pbb – hQC catalytic domain + inhibitor
    
  • 4ywy, 6gbx, 7coz – hQC (mutant) + inhibitor
    
  • 6yi1 – hQC + Glu-(γ-hydrazide)-Phe-Ala
    
  • 6yjy – hQC + neurotensin
    
  • 3si2 – mQC + inhibitor
    
  • 7d1d – BtQC + imidazole derivative – Bacterioides thetaiotaomicron
    
  • 7d1e – BtQC + N-acetylhistamine
    
  • 4mhz – IsQC catalytic domain (mutant) + inhibitor
    
  • 4mhy – IsQC catalytic domain + imidazole derivative
    

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