Glycerol kinase

spinqualitylabelsall models Glycerol kinase complex with glycerol (PDB entry 1xup) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Glycerol kinase or ATP:glycerol 3-phosphotransferase (GK) phosphorylates glycerol forming glycerol 3-phosphate (G3P) using Mg-ATP as phosphate source. GK is a key enzyme in glycerol uptake and metabolism. Mutations of GK gene cause GK deficiency syndrome. PK is a multi-subunit allosteric enzyme. Its activity can be inhibited by fructose 1,6-bisphosphate (FBP) and by the glucose-specific phosphocarrier IIA(Glc). PK cofactor is a Zn atom which binds to the dimer. Disease GK Deficiency is an X-linked disease which has 3 forms: infantile, juvenile and adult Structural highlights GK active site is located in a cleft between two domains.

3D structures of glycerol kinase

Updated on 14-May-2026

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• Glycerol kinase
  • 1r59 – EncGK – Enterococcus casseliflavus
    
  • 2dpn - GK - Thermus thermophilus
    
  • 2d4w - GK - Cellulomonas
    
  • 2zf5 - TkGK - Thermococcus kodakarensis
    
  • 3gg4 – GK – Yersinia pseudotuberculosis
    
  • 3wxi – TbGK – Trypanosoma brucei gambiense
    
  • 6zq5, 6zq8 – CtGK – Chaetonium thermophilum
    
• Glycerol kinase binary complex
  • 1xup - EncGK + glycerol
    
  • 3flc, 3d7e, 3h3n, 3h46 - EncGK (mutant) + glycerol
    
  • 3g25 - SaGK + glycerol– Staphylococcus aureus
    
  • 4e1j – GK + glycerol – Sinorhizobium meliloti
    
  • 1bu6, 3ezw - EcGK (mutant) + glycerol
    
  • 3wxk, 6j9x, 6jae, 6jaf – TbGK + glycerol
    
  • 6zq4, 6zq6, 6zq7 – CtGK + glycerol
    
  • 6k76 – TkGK + AMPPNP
    
  • 6k78, 6k79 – TkGK + glycerol
    
  • 8pry – GK + glycerol – Trypanosoma cruzi
    
• Glycerol kinase ternary complex
  • 1gla – EcGK + IIA(Glc) + glycerol – Escherichia coli
    
  • 1glb - EcGK + IIA(Glc) + ADP + glycerol
    
  • 1glc, 1gld, 1gle – EcGK + G3P + ADP
    
  • 1glf - EcGK + phosphate + ADP + glycerol
    
  • 1bo5 - EcGK + FBP + glycerol
    
  • 1bot - EcGK + piperazine derivative + glycerol
    
  • 1bwf, 1glj, 1gll - EcGK (mutant) + ATP analog + glycerol
    
  • 3ge1 - SaGK + ADP + glycerol
    
  • 3h3o - EncGK (mutant) + phosphate + glycerol
    
  • 3h45 - EncGK (mutant) + phosphate + ethylene glycol
    
  • 3wxj – TbGK + glycerol + G3P
    
  • 3wxl, 6j9v – TbGK + glycerol + ADP
    
  • 8y1t – TbGK + glycerol + ADP + G3P
    
  • 6j9q – TbGK + glycerol + AMPPNP
    
  • 5azi, 5azj – TbGK + glycerol + nitrophenyl-phosphate
    
  • 5gn5, 5gn6 – TbGK + glycerol + coumarin derivative
    
  • 6ude – GK + glycerol + ADP – Elizabethkingia anophelis
    

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