Glycolate oxidase

spinqualitylabelsall models Human glycolate oxidase 1 complex with glyoxylate and FMN (PDB entry 2rdu) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Glycolate oxidase (GOX) or hydroxyacid oxidase catalyzes the conversion of (S)-2-hydroxy acid and molecular oxygen to 2-oxo acid and hydrogen peroxide. In higher plants, GOX catalyzes the oxidation of glycolate to glyoxylate. GOX is part of the glyoxylate and dicarboxylate metabolism and uses FMN as a cofactor. GOX catalyzes the first step in the utilization of glycolate as the sole source of carbon. Disease Mutations in GOX result in isolated asymptotic hyperoxaluria type I. Structural highlights The biological assembly of human glycolate oxidase 1 homotetramer. GOX structure shows the typical β8/α8 fold (Alpha Helices,  Beta Strands ,  Loops , Turns ) of an α-hydroxy acid oxidase and its active site contains the cofactor FMN. Water molecules are shown as red spheres. 3D structures of glycolate oxidase Glycolate oxidase 3D structures

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