Growth factor receptor-bound protein

spinqualitylabelsall models Structure of human Grb2 SH2 domain (green) complex with phosphotyrosyl polypeptide (magenta) (PDB entry 1bmb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Growth factor receptor-bound proteins (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. GRB2 links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. GRB7 interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway. GRB10 and GRB14 interact with insulin receptor and insulin-like growth factor receptors. For additional details on GRB10 see Grb10 SH2 Domain. Structural highlights Human GRB2 residue Trp121 forces the phosphotyrosyl containing ligand into a turn conformation. Water molecules are shown as red spheres. Phosphotyrosine binding . 3D structures of growth factor receptor-bound proteins Growth factor receptor-bound proteins 3D structures

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