Guanine nucleotide dissociation inhibitor

spinqualitylabelsall models Structure of mouse guanine nucleotide dissociation inhibitor (green) complex with GTPase RhoA (grey), geranyl geran, phosphoaminophosphonic acid-guanylate ester and Mg+2 ion (green) (PDB code 4f38). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Guanine nucleotide dissociation inhibitor or Rho GDP-dissociation inhibitor (GDI) bind to GDP-bound Rho (RhoGDI) and Rab small GTPase maintaining it in an off-stage and preventing the GTPase localization to the membrane. Relevance Levels of RhoGDI are significantly low in tumor tissues.

3D structures of guanine nucleotide dissociation inhibitor

Updated on 25-April-2023

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• RhoGDI
  • 1rho – hGDI1 (mutant) – human
    
  • 1fso, 1fst, 1ft0, 1ft3, 1kmt, 1qvy, 2bxw, 2jhs, 2jht, 2jhu, 2jhv, 2jhw, 2jhx, 2jhy, 2jhz, 2ji0 – hGDI1 C-terminal (mutant)
    
  • 5h1d – hGDI2
    
  • 1ajw, 1gdf – bGDI1 C-terminal – bovine - NMR
    
  • 1d5t, 1gnd – bGDI1
    
• RhoGDI complex
  • 1hh4 – hGDI1 + Ras-related C3 botulinum toxin substrate 1
    
  • 4f38 – mGDI1 + GTPase RhoA - mouse
    
  • 1cc0, 1doa – bGDI1 + GTPase RhoA
    
  • 5fr1, 5fr2 – bGDI1 + RhoA
    
  • 1lv0 – bGDI1 + geraylgeranyl peptide
    

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