Guanylate cyclase

spinqualitylabelsall models Human GC subunitα-1 (cyan) complex with subunit β-1 (green) and the activator cinaciguat (PDB ID 7d9t) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Guanylate cyclase. (GC) catalyse the conversion of GTP to cGMP and pyrophosphate. cGMP is a second messenger that modulates various processes like platelet aggregation, neurotransmission, sexual arousal, gut peristalsis, blood pressure and more. Disease Mutations in retinal GC are involved in inherited retinopathy. Relevance A GC activator - Cinaciguat - is investigated as add-on to therapy of patients suffering from acute heart failure syndrome, . Structural highlights The 3D structure of heterodimer of human GC subunit α-1 complex with subunit β-1 and the activator cinaciguat shows the cinaciguat activator binding in the haem-binding pocket of subunit β-1 and replacing the haem. The activator makes various interactions with the β-1 subunit. 3D structures of granulate cyclase Guanylate cyclase 3D structures

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Michal Harel, Alexander Berchansky