Gyrase

spinqualitylabelsall models Gyrase subunit A N-terminal (cyan) and subunit B C-terminal (magenta) complex with DNA, inhibitor, sulfate and Mn+2 ion (purple) (PDB entry 4plb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Gyrase (Gyr) is a type of topoisomerase II in prokaryotes which unwinds double stranded DNA. The DNA Gyr cutting allows the formation of a negative DNA supercoil which enables replication of DNA Gyr consists of 2 subunits: GyrA and GyrB. Reverse gyrase (Top-RG) is a type of topoisomerase I which catalyses the formation of positive DNA supercoil. See also Isomerases. Relevance GyrA inhibitor Ciprofloxacin is used as antibiotic drug. Fluoroquinolones are Gyr inhibitors used in treatment of multi drug-resistant tuberculosis Structural highlights Gyrase subunit A N-terminal and subunit B C-terminal complex with DNA and inhibitor. A potential drug interacts with both DNA strands and in the hydrophobic pocket between subunits A and B. Water molecules shown as red spheres. 3D Structure of Gyrase Gyrase 3D Structures

Additional Resources

For additional information, see: Isomerases

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