Horseradish peroxidase

spinqualitylabelsall models Horseradish peroxidase containing heme group complex with benzhydroxamic acid and Ca+2 ion (green) (PDB entry 2atj) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Horseradish peroxidase (HRP) catalyzes the oxidation of luminol to 3-aminophthalate using hydrogen peroxide. The reaction is accompanied by emission of light. In the presence of chemicals, particularly – p-iodophenol, the light emission is enhanced 1000-fold. Upon addition of the proper substrate, the HRP complex emits colored light. HRP contains a heme group. Relevance HRP isozyme C1a is widely used for detection of a labeled molecule to which it conjugates. Structural highlights The active site contains a heme group and the substrate benzhydroxamic acid. Fe coordination site. Water molecules shown as red spheres.

3D structures of horseradish peroxidase

Updated on 14-September-2025

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• Horseradish peroxidase
  • 1atj, 1g57, 1g5i, 1g5j, 1g5k, 1g5m, 1h55, 1h57, 1h58, 1h5c, 1h5d, 1h5e, 1h5f, 1h5g, 1h5h, 1h5i, 1h5j, 1h5k, 1h5l, 1hch, 9h1m – HRP C1a
    
  • 1kzm, 1gwo, 1gwt, 1gwu, 2ylj - HRP C1a (mutant)
• Horseradish peroxidase binary complex
  • 2atj – HRP C1a + benzhydroxamic acid
    
  • 3atj, 4atj, 1gx2 - HRP C1a (mutant) + benzhydroxamic acid
    
  • 6atj - HRP C1a + ferulic acid
    
  • 1gw2 - HRP C1a (mutant) + ferulic acid
    
  • 7atj - HRP C1a + CN + ferulic acid
    
  • 1h5a – HRP C1a + acetate
    
  • 1w4w - HRP C1a + formate
    
  • 1w4y - HRP C1a + CO

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