Hydroxysteroid dehydrogenase 3D structures

3D structures of hydroxysteroid dehydrogenase

Updated on 29-March-2026

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• 3-α HSD or AKR1C2
• For 3-α HSD type 2 see Prostaglandin F synthase
  • 1ral – rHSD – rat
    
  • 1fjh - CtHSD – Comamonas testosterone
    
  • 4is2 – CsHSD – Clostridium scindens
    
  • 7p36, 8kc6 - LkHSD – Lactobacillus kefiri
    
  • 8kcn - LkHSD (mutant)
    
• 3-α HSD binary complex
  • 2fvl, 2hdj - hHSD + NADP - human
    
  • 1lwi – rHSD + NADP
    
  • 1fk8 – CtHSD + NAD
    
  • 2dkn - HSD + NAD – Pseudomonas
    
  • 4is3 - CsHSD + NAD
    
  • 7ejh, 7eji, 7ejj, 7vdo, 7vet - LkHSD (mutant`) + NADP
    
• 3-α HSD ternary complex
  • 4jq1, 4jq2, 4jq3, 4jq4, 4jqa, 4jtq, 4jtr - hHSD + NSAID drug + NADP
    
  • 1afs - rHSD + hydroxysteroid + NADP
    
• 3-α HSD type 3
  • 2hdj - hHSD + NADP
    
  • 1ihi, 1j96 - hHSD + hydroxysteroid + NADP
    
  • 1xjb - hHSD + citrate+ acetate + NADP
    
  • 4l1w - hHSD + progesterone + NADP
    
  • 4l1x - hHSD (mutant) + progesterone + NADP
    
  • 4xo6, 4xo7 – hHSD + NADP + epiandrosterone derivative
    
• 7-α HSD
  • 3gaf - BmHSD – Brucella melitensis
    
  • 8hax, 8hde, 8hdi, 8hdn, 8hs6, 8hs9 - BmHSD (mutant)
    
  • 8hs4, 8hs5, 8hsa - BmHSD (mutant) + NAD
    
  • 7eny – EcHSD – Escherichia coli
    
  • 1ahh – EcHSD + NAD
    
  • 1ahi, 1fmc – EcHSD + hydroxysteroid + NAD
    
  • 5epo – HSD + NADP – Clostridium sardiniese
    
• 7-beta HSD
  • 5fyd – CaHSD – Collinsella aerofaciens<br />
  • 5gt9 – CaHSD + NADP
    
• 20-α HSD or AKR1C1
  • 6a7a, 8jp2 – hHSD + NADP + inhibitor
    
  • 1q5m - raHSD + NADP – rabbit
• 20-α HSD ternary complex
  • 1mrq – hHSD + hydroxysteroid + NADP
    
  • 4yvp – hHSD + NADP + sulfonylurea derivative
    
  • 3c3u, 3nty - hHSD + inhibitor + NADP
    
  • 3gug - hHSD (mutant) + inhibitor + NADP
    
  • 6ijx – hHSD + NADP + meclofenamic acid
    
  • 1q13 - raHSD + hydroxysteroid + NADP
    
• 20-beta HSD
  • 6m9u – BaHSD – Bifidobacterium adolescentis
    
  • 6ow4 – BaHSD + NADP
    
• 11-β HSD or corticosteroid 11-β-dehydrogenase 1
  • 1xu7, 1xu9 - hHSD (mutant) + NADP
    
  • 2pd6 - hHSD + NAD
    
  • 3hb4 - hHSD + inhibitor
    
  • 3dey - hHSD + hydroxysteroid
    
  • 1y5m - mHSD + NADP - mouse
    
  • 1xse - gpHSD catalytic domain + NADP – guinea pig
    
  • 3dwf, 3lz6 - gpHSD catalytic domain (mutant) + NADP
    
• 11-β HSD ternary complex
  • 2bel - hHSD 1 + hydroxysteroid + NADP
    
  • 2irw, 2ilt, 4bb5, 4bb6, 4yyz - hHSD 1 + inhibitor + NADP
    
  • 2rbe, 3byz, 3bzu, 3ch6, 3czr, 3d3e, 3d4n, 3d5q, 3ey4, 3fco, 3frj, 3h6k, 3hfg, 3oq1, 3pdj, 3qqp, 3tfq, 4c7j, 4c7k, 4p38, 5pgu, 5pgv, 5pgw, 5pgx, 5pgy, 5pgz, 5pii, 5pij, 5qii - hHSD 1 (mutant) + inhibitor + NADP
    
  • 6nj7 - hHSD 1 + colleic acid + NAP
    
  • 3g49 - gpHSD catalytic domain + inhibitor + NADP
    
  • 1y5r, 3gmd - mHSD 1 + hydroxysteroid + NADP
    
  • 4k26, 5qij - mHSD 1 + inhibitor + NADP
    
  • 4nmh - mHSD 1 (mutant) + inhibitor + NADP
    
• 17-α HSD or AKR1C21
  • 2he8 – mHSD - mouse
    
  • 3fjn - mHSD (mutant)
    
  • 2he5, 2hej, 2p5n - mHSD + NADP
    
  • 2ipf - mHSD + hydroxysteroid + NADP
    
  • 2ipg, 2ipj - mHSD (mutant) + hydroxysteroid + NADP
    
  • 3cv6 - mHSD (mutant) + inhibitor + NADP
    
• 17-β HSD or estradiol 11-β-dehydrogenase 1
• For 17-β HSD type 5 or AKR1C3 see Prostaglandin F synthase
  • 1bhs – hHSD 1
    
  • 1s9c - hHSD 4 (mutant)
    
  • 8g9v – hHSD 13
    
  • 5ics – hHSD 14
    
  • 3is3 – ClHSD – Cochliobolus lunatus
    
  • 3itd - ClHSD (mutant)
• 17-β HSD binary complex
  • 1fds, 1iol, 1jtv, 1yb1, 3dhe, 3klm, 3klp, 3km0 - hHSD + hydroxysteroid
    
  • 1dht, 1fdw - hHSD (mutant) + hydroxysteroid
    
  • 6mnc – hHSD 1 + estrone
    
  • 1fdv - hHSD 1 (mutant) + NAD
    
  • 1equ, 1qyv - hHSD 1 + NADP
    
  • 1i5r, 6dtp - hHSD 1 + inhibitor
    
  • 1zbq - hHSD 4 + NAD
    
  • 2o23 – hHSD 10 + NAD
    
  • 5en4, 5icm, 5l7t, 5l7w, 5l7y - hHSD 14 + inhibitor
    
  • 5js6, 5jsf, 6h0m, 6hno - hHSD 14 (mutant) + NAD
    
  • 8g93 - HSD 13 (mutant) + NAD - dog
    
  • 3qwf - ClHSD + NADP
    
  • 4fiz, 4fj0, 4fj1, 4fj2 – ClHSD + dehydroxy flavonoid inhibitor
    
• 17-β HSD ternary complex
  • 1fdt, 1qyw, 1qyx - hHSD 1 + hydroxysteroid + NADP
    
  • 1a27, 1fdu - hHSD 1 (mutant) + hydroxysteroid + NADP
    
  • 3hb5, 6cge - hHSD 1 + inhibitor + NADP
    
  • 4hfr, 4hx5, 4iju, 4ijv, 4ijw, 4k1l, 6cgc - hHSD 1 (mutant) + inhibitor + NADP
    
  • 6mne, 7x3z – hHSD 1 + NADP + estrone
    
  • 5o42, 5o43, 5o6o, 5o6x, 5o6z, 5o72 - hHSD 14 + inhibitor + NAD
    
  • 5hs6 - hHSD + NAD + estrone
    
  • 4cql - hHSD 8 + carbonyl reductase + NAD
    
  • 4cqm - hHSD 8 + carbonyl reductase + NADP
    
  • 5o42, 5o43, 5o6o, 5o6x, 5o6z, 5o72, 6qck - hHSD 14 + inhibitor + NAD
    
  • 5o7c, 6ffb, 6g4l, 6gbt, 6gtb, 6gtu, 6zde, 6zdi, 6zr6, 6zra, 6zt2 - hHSD 14 (mutant) + inhibitor + NAD
    
  • 6emm - hHSD 14 (mutant) + salicilate + NAD
    
  • 5hs6 - hHSD 14 + NAD + estrone
    
  • 3qwh, 3qwi - ClHSD + hydroxysteroid + NADP
    
• 3-α 20-β HSD
  • 2hsd – SeHSD – Streptomyces exfoliates
    
  • 1hdc – SeHSD + inhibitor
• Carbonyl reductase/20-β HSD
  • 1n5d - HSD + NADP – pig
    
• 3-β/17-β HSD
  • 1hxh - CtHSD

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Michal Harel, Openfox