Im3

Im3 is the Colicin Immunity Protein produced by E. coli cells alongside Colicin E3 to prevent the Colicin's RNase activity from killing the cell. Once the complex has been released by the producing E. coli it then binds to a target cell, and upon binding the immunity protein is released from the ColE3 cytotoxic domain.

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Colicin-E3 immunity protein complex with colicin E3, 1jch
Ligands:	CIT, GOL
Related:	3eip, 1e44
Structural annotation: Resources: CATH : 1Jchb00, 1Jchd00 InterPro : Ipr009105, Ipr003058, Ipr003063 Pfam : PF03515, PF09000, PF03513 SCOP : d1jcha3, d1jcha2, d1jcha1, d1jchb_, d1jchc2, d1jchc3, d1jchc1, d1jchd_ UniProt : P00646, P02984
Functional annotation: Cellular component: extrachromosomal circular DNA Biological process: pathogenesis cytolysis defense response to bacterium bacteriocin immunity Molecular function: nucleic acid binding ribosome binding receptor binding nuclease activity endonuclease activity hydrolase activity hydrolase activity, acting on ester bonds RNA binding protein binding toxin binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

3D structures of colicin-E3 immunitiy protein

Colicin Immunity Protein

Proteopedia Page Contributors and Editors (what is this?)

Gemma McGoldrick, Michal Harel