Insulin-like growth factor

spinqualitylabelsall models Structure of insulin-like growth factor I complex with detergent (PDB entry 1gzr) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Insulin-like growth factor (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme. IGF I is secreted in the liver after stimulation by growth hormone. See details in IGF1 and Igf1 - alec. IGF II is required in early development stages. Relevance Inhibition of IGF I influences colon cancer. IGF I has protective effect in neuropathy. See also Insulin-like growth factor receptor and Insulin-like growth factor 1.

3D structures of insulin-like growth factor

Updated on 22-September-2025

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• IGF I
  • IGF1, Igf1 - alec, Insulin-like growth factor receptor, Insulin-like growth factor 1 - hIGF I + inhibitor – human - Cryo EM
    
  • 8eyr, 8x06, 8x2m, 8xjs, 8xkm, 8xkr - hIGF I + IGFI receptor – Cryo EM
    
• IGF I residues 49-118
  • 2gf1, 3gf1, 1b9g, 1bqt, 6rva – hIGF I – NMR
    
  • 3lri - hIGF I (mutant) – NMR
    
  • 1imx, 1gzr, 1gzy, 1gzz, 1h02 - hIGF I
    
  • 1tgr - hIGF I (mutant)
    
  • 1pmx – hIGF I + peptide - NMR
    
  • 1h59 – hIGF I + IGF binding protein 5
    
  • 2dsp, 2dsr - hIGF I + IGF binding protein 4
    
  • 1wqj - hIGF I + IGF binding protein 4
    
  • 2dsq - hIGF I + IGF binding protein 4 + IGF binding protein 1
    
  • 4xss - hIGF I + insulin receptor + insulin-like growth factor receptor peptide
    
  • 5u8q - hIGF I + IGFI receptor + antibody
    
  • 6ff3 - hIGF I + neural ectodermal development factor
    
  • 6pyh - hIGF I + mIGFI receptor – Cryo EM
    
  • 7wrq - hIGF I + IGFBP3 + ALS – Cryo EM
    
  • 7s0q - hIGF I + IGFI receptor + insulin receptor – Cryo EM
    
• IGF II
  • 8u4c, 8u4e, 8vjb, 8vjc, 8ysz - hIGF II + insulin receptor – Cryo EM
    
• IGF II residues 25-91
  • 1igl, 5l3l, 5l3m, 5l3n - hIGF II – NMR
    
  • 3e4z – hIGF II + insulin-degrading enzyme
    
  • 3kr3 - hIGF II + antibody
    
  • 6um2 - hIGF II + bIGFII receptor – Cryo EM
    
  • 6vwg, 6vwi - hIGF II + IGFI receptor – Cryo EM
    

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Michal Harel, Alexander Berchansky