Interferon receptor

spinqualitylabelsall models Structure of interferonα/β receptor β chain ectodomain (yellow) complex with interferon-α 2 (pink) and Cl- ion (green) (PDB entry 3s9d) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Interferon receptor (IFNR) is a cell surface receptor which binds interferon. Interferon α/β receptor binds interferon-α and interferon-β. It is a heterodimer with subunits INFAR1 and INFAR2. For more details see IFNAR and Multiple sclerosis. Interferon γ receptor binds interferon-γ and is a heterodimer with subunits INFGR1 and INFGR2. Interferon δ receptor binds interferon-δ. See also: Cytokine receptors. Relevance Lack of neuronal interferon α/β receptor causes Lewy Body and Parkinson-like dementia in mice. Interferon α/β receptor deficiency has a role in the pathogenesis of lupus. Disease Mutations of interferon γ receptor confer susceptibility to infections caused by mycobacteria. 3D structures of interferon receptor Interferon receptor 3D structures

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Michal Harel