Isopentenyl-diphosphate delta-isomerase

spinqualitylabelsall models Structure of E. coli isopentenyl-diphosphate delta-isomerase complex with EIPP, Mg+2 (green) and Mn+2 (purple) ions and EIPP (PDB code 1nfz). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Isopentenyl-diphosphate delta-isomerase (IPPI) catalyzes the conversion of the un-reactive isopentenyl diphosphate (IPP) to the more reactive dimethylallyl diphosphate (DMAPP). 3,4-epoxy-3-methyl butyl diphosphate (EIPP) is an irreversible inhibitor of IPPI. IPPI participates in isoprenoid biosynthesis. See also Mevalonate pathway Structural highlights E. coli IPPI contains 2 divalent ions which interact with the irreversible inhibitor EIPP. Water molecules shown as red spheres. Mg coordination site. Mn coordination site.

3D structures of isopentenyl-diphosphate delta-isomerase

Updated on 16-January-2023

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• Isopentenyl-diphosphate delta-isomerase
  • Mevalonate pathway – hIPPI + Mg - human
    
  • 2dho – hIPPI 1 (mutant) + Mn
    
  • 1i9a, 2vnq – EcIPPI + Mn – Escherichia coli
    
  • 1hx3 – EcIPPI (mutant) + Mn
    
  • 1r67 – EcIPPI (mutant) + Mg
    
  • 2g74 – EcIPPI (mutant) + Mg + Mn
    
  • 1hzt – EcIPPI
    
  • 1p0k – BsIPPI – Bacillus subtilis
    
  • 1p0n – BsIPPI + FMN
    
  • 1vcf – TtIPPI + FMN + Cd – Thermus thermophilus
    
  • 1vcg – TtIPPI + FMN
    
  • 2zru, 2zrv, 3vkj – SsIPPI + FMN – Sulfolobus shibatae
    
  • 3hyq – IPPI – Salmonella enterica
    
  • 3sr7 – IPPI – Streptococcus mutans
    
  • 4n02 – IPPI + FMN – Streptococcus pneumoniae
    
• Isopentenyl-diphosphate delta-isomerase complex
  • 2i6k – hIPPI (mutant) + Mn + Mg + aminoethanol-PP
    
  • 2ick – hIPPI + Mn + dimethylallyl-PP
    
  • 2pny – hIPPI 2 + Mn + PP
    
  • 1nfs, 2vnp – EcIPPI + Mn + Mg + dimethylamino-ethyl-PP
    
  • 1pvf – EcIPPI + Mn + Mg + PP
    
  • 1nfz, 1ppw, 1x84 – EcIPPI + Mn + Mg + EIPP
    
  • 1ow2, 1x83, 2g73, 2b2k – EcIPPI (mutant) + Mn + Mg + EIPP
    
  • 1ppv – EcIPPI + Mn + Mg + bromo-EIPP
    
  • 1q54 – EcIPPI (mutant) + Mn + Mg + bromo-EIPP
    
  • 3dh7 – TtIPPI + FMN + PP
    
  • 3b05, 2zrw, 2zry – SsIPPI + FMN + Mg + IPP
    
  • 3b06, 2zrx, 2zrz – SsIPPI + FMN + Mg + DMAPP
    
  • 3b03, 3b04 – SsIPPI + Mg + inhibitor
    

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