Janus kinase 3D structures

3D Structures of Janus kinase

Updated on 08-October-2025

{"openlevels":0}

• JAK1
• JAK1 kinase or JH1 domain residues 869-1153
  • 4e4l, 4e4n, 4e5w, 4ehz, 4ei4, 4fk6, 4i5c, 4k6z, 3eyg, 3eyh, 5e1e, 5hx8, 5khx, 6n77, 6n78, 6n79, 6n7a, 6n7b, 6n7c, 6n7d, 6elr, 6dbn, 4k77, 6bbu, 5wo4, 6w8l, 6hzu, 6rsb, 6rsc, 6rsd, 6rse, 6rsh, 6sm8, 6smb, 6tpe, 6tpf, 6vnb, 6vnc, 6vne, 6vnf, 6vng, 6vnh, 6vni, 6vnj, 6vnk, 6vnl, 6vnm, 6vs3, 6vsn, 6wtq, 8s85 - hJAK1 kinase domain + PTyr + inhibitor - human
    
  • 5khw – hJAK1 kinase domain + PTyr + ADP
    
  • 6c7y]] – hJAK1 kinase domain + PTyr + SOCY1 + ADP
    
  • 6aah, 6aaj, 6vgl, 6vn8, 6wtn, 6wto – hJAK1 kinase domain + PTyr + drug
    
• JAK1 pseudokinase domain residues 561-860
  • 4l00 – hJAK1 pseudokinase domain
    
  • 4l01 – hJAK1 pseudokinase domain (mutant)
    
• JAK1 FERM-SH2 domain residues 36-514
  • 5ixd, 5l04 – hJAK1 + IFN l receptor
    
  • 5ixi – hJAK1 + IFN l receptor/IL10
    
  • 6e2p – hJAK1 + leptin receptor
    
  • 6e2q – hJAK1 + erythropoietin receptor
    
• JAK2
• JAK2 kinase domain residues 536-812
  • 4fvp - hJAK2 kinase domain
    
  • 8c08 – hJAK2 kinase domain (mutant) + ATP
    
  • 3ugc, 4bbe, 4bbf, 3zmm, 2xa4, 4c61, 4c62, 5l3a, 5tq3, 5tq4, 5tq5, 5tq6, 5tq7, 5tq8, 6tpd, 8g8x – hJAK2 kinase domain (mutant) + inhibitor
    
  • 3e62, 3e63, 3e64, 2w1i, 4ytc, 4ytf, 4yth, 4yti, 4zim, 5aep, 5cf4, 5cf5, 5cf6, 3io7, 3iok, 3kck, 3jy9, 3lpb, 3krr, 3q32, 3tjc, 3tjd, 3rvg, 4aqc, 4e4m, 4f09, 4hge, 4d0w, 4d0x, 4d1s, 4p7e, 4aep, 5cf8, 6ggh, 7ree – hJAK2 kinase domain + PTyr + inhibitor
    
  • 2b7a, 3fup, 4e6d, 4e6q, 4f08 – hJAK2 kinase domain (mutant) + PTyr + inhibitor
    
  • 6aaj – hJAK2 kinase domain (mutant) + PTyr + drug
    
  • 4gl9 – mJAK2 kinase domain + PTyr + inhibitor + suppressor of cytokine signaling 3 + interleukin 6 receptor subunit β - mouse
    
• JAK2 JH1 domain residues 833-1132
  • 4gfm, 4gmy, 4iva, 4ivb, 4ivc, 4ivd, 4ji9, 4jia, 5usy, 5usz, 5ut0, 5ut1, 5ut2, 5ut3, 5ut4, 5ut5, 5ut6, 6drw, 5wev - hJAK2 JH1 domain + PTyr + inhibitor
    
  • 5hez - hJAK2 JH1 domain (mutant) + PTyr + inhibitor
    
  • 6bbv, 6wtp, 7ll4, 7ll5, 7q7i, 7q7k, 7q7l, 7q7w, 7rn6, 7teu, 7uyw - hJAK2 JH1 domain + inhibitor
    
  • 8bm2, 8bpv, 8bpw, 8bx6, 8bx9, 8bxc, 8bxh - hJAK2 JH1 domain + drug
    
• JAK2 JH2 or pseudokinase domain residues 536-812
  • 7f7w – hJAK2 JH2 domain
    
  • 8c09, 8c0a – hJAK2 JH2 domain (mutant)
    
  • 6obb, 7t0p - hJAK2 JH2 domain + inhibitor
    
  • 6brw, 6d2i, 6bs0, 6bss, 5wij, 5wik, 5wil, 5wim, 5win, 6g3c, 6m9h, 6oav, 6obf, 6obl, 6occ, 6x8e, 6xjk, 7jyo, 7jyq, 7szw, 7t1t, 8b8n, 8b8u, 8b99, 8b9e, 8b9h, 8ba2, 8bab, 8bak, 8ex0, 8ex1, 8ex2, 8g6z, 8g8o - hJAK2 JH2 domain (mutant) + inhibitor
    
  • 8ba3, 8ba4 - hJAK2 JH2 domain (mutant) + drug
    
  • 3ugc – hJAK2 JH2 domain (mutant)
    
  • 4fvq, 4fvr, 5i4n – hJAK2 JH2 domain (mutant) + ATP
    
• JAK2 FERM-SH2 domain residues 31-516
  • 4z32 – hJAK2
    
• JAK3
• JAK3 kinase domain residues 810-1100
  • 1yvj – hJAK3 kinase domain (mutant) + PTyr + staurosporine analog
    
  • 3lxk, 3lxl, 5wfj – hJAK3 kinase domain (mutant) + PTyr + inhibitor
    
  • 3pjc, 4v0g, 4z16, 5lwm, 5lwn, 5toz, 6glb, 6gl9, 6gla, 6ny4, 6dud, 6da4, 7apf, 7apg, 7q6h, 7uyv, 9r5z – hJAK3 kinase domain + inhibitor
    
  • 4hvd, 4hvg, 4hvh, 4hvi, 3zc6, 3zep, 4i6q, 4qps, 4rio, 4qt1, 5tts, 5ttu, 5ttv, 5vo6, 6db3, 6db4 – hJAK3 kinase domain (mutant) + inhibitor
    
  • 5w86, 6hzv – hJAK3 kinase domain + PTyr + inhibitor
    
  • 7c3n – hJAK3 kinase domain + PTyr + drug
    
  • 6aak – hJAK3 kinase domain (mutant) + PTyr + drug
    
• JAK
  • 7t6f, 8ewy – mJAK + interferon lambda receptor 1
    
• TYK2 see Tyrosine kinase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel