| Function
L-rhamnose isomerase (LRI) catalyzes the interconversion of L-rhamnose to L-rhamnulose or D-allose to D-psicose. LRI participates in fructose and mannose metabolism[1].
Structural highlights
The biological assembly of LRI from Escherichia coli is homotetramer. The active site of LRI contains catalytic Zn+2 and Mn+2 ions[2]. Water molecules shown as red spheres.
- ↑ Leang K, Takada G, Fukai Y, Morimoto K, Granstrom TB, Izumori K. Novel reactions of L-rhamnose isomerase from Pseudomonas stutzeri and its relation with D-xylose isomerase via substrate specificity. Biochim Biophys Acta. 2004 Sep 6;1674(1):68-77. PMID:15342115 doi:https://dx.doi.org/10.1016/j.bbagen.2004.06.003
- ↑ Korndorfer IP, Fessner WD, Matthews BW. The structure of rhamnose isomerase from Escherichia coli and its relation with xylose isomerase illustrates a change between inter and intra-subunit complementation during evolution. J Mol Biol. 2000 Jul 21;300(4):917-33. PMID:10891278 doi:https://dx.doi.org/10.1006/jmbi.2000.3896
|
3D structures of L-rhamnose isomerase
Updated on 20-October-2025
{"openlevels":0}
- L-rhamnose isomerase
- LRI complexes with reactants
- 1de5, 1de6 – EcLRI + L-rhamnitol
- 2i56, 3itt, 3m0h, 3m0v, 3m0y – PsLRI (mutant) + L-rhamnose
- 3itl – PsLRI (mutant) + L-rhamnulose
- 2i57, 3m0m – PsLRI (mutant) + D-allose
- 3ito, 3itv, 3m0l, 3m0x – PsLRI (mutant) + D-psicose
- 4gji – PsLRI (mutant) + L-rhamnopyranose
- 4gjj – PsLRI (mutant) + D-alloopyranose
- 8jq3 – LrLRI – Lactobacillus rhamnosus
- 8jq6 – LrLRI + D-allose
- 8jq4 – LrLRI + L-rhamnulose
- 8jq5 – LrLRI + D-allulose
References
proteopedia link