Laminin

spinqualitylabelsall models Human laminin integrin binding domain. Subunitα-5 (grey, yellow), subunit β-1 (green, light pink), subunit γ-1 (yellow, cyan) and Ca+2 (green) (PDB code 5xau) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Laminins (LAM) are a family of glycoproteins that provide the integral part of the structural scaffolding of basement membranes in almost every animal tissue. Laminins are heterotrimers containing α-, β- and γ-subunits. Laminins are essential for early embryonic development and organogenesis and have crucial functions in tissues like muscles, lung, skin, kidney and nerve. Several members of the integrin family serve as laminin receptors on a variety of cell types. - Relevance Serum concentration of laminin is increased in patients with inflammatory bowel disease hence can be used as a marker for sustained inflammation. Laminin was found to have an anti-amyloidogenic effect and γmay be of therapeutic value in Alzheimer Disease. Laminin-111 was found to be a highly therapeutic agent in mice with Duchenne muscular dystrophy. Structural highlights The interaction os laminin with integrin β1 metlion-dependent adhesion site is via the LAM γ chain tail. The critical LAM residue for binding integrin is a Glu residue in chain γ-1.

3D structures of laminin

Updated on 22-October-2025

8dmk - hLAM subunit α-1+beta-1+gamma-1 – human – Cryo EM
4yeq, 4yep - hLAM subunit α-2 L4b domain 1177-1379
5xau - hLAM integrin-binding domain subunit α-5 2655-3327 + hLAM subunit β-1 1714-1786 + hLAM subunit γ-1 1528-1609 (mutant)
7cec - hLAM integrin-binding domain subunit α-5 2655-3327 (mutant) + hLAM subunit β-1 1714-1786 + hLAM subunit γ-1 1528-1609 + integrin α6β1– Cryo EM
9az3 - hLAM subunit gamma-1 – Cryo EM
5lf2 - rLAM subunit β-2 LE5-LF-LE6 domain 523-833 - rat
2jd4 - mLAM subunit α-1 LG4-5 domain 2706-3084 (mutant) - mouse
2wj8 - mLAM subunit α-2 LG1-3 domain 2136-2746
5ik7, 5ik4, 5ik8, 5ik5 - mLAM subunit α-2 LG4-5 domain 2729-3118
1dyk, 1okq - mLAM subunit α-2 LG4-5 domain 2729-3118 (mutant)
1qu0 - mLAM subunit α-2 LG5 domain 2932-3106 (mutant)
2y38 - mLAM subunit α-5 LN-LEA1-2 domain 44-433
1tle - mLAM subunit γ-1 LE domain 824-881 - NMR
4aqt - mLAM subunit γ-1 LN-LE2 domain 53-395
4aqs - mLAM subunit γ-1 LN-LE4 domain 22-542
1klo - mLAM subunit γ-1 module III 3-5 771-932
1npe - mLAM subunit γ-1 module III 3-5 + nidogen G3 YWTD domain
5mc9 - mLAM integrin-binding domain subunit α-1 2079-2707 + mLAM subunit β-1 1735-1786 + mLAM subunit γ-1 1548-1607

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Michal Harel, Alexander Berchansky