Leukotriene B4 hydroxydehydrogenase

spinqualitylabelsall models Guinea pig leukotriene B4 12-hydroxydehydrogenase complex with oxo-PGE2, NADP an Cl- ion (green)(PDB entry 1v3v) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin reductase (LB4H) is a bifunctional enzyme. It is part of the arachidonic acid cycle and is part of the metabolism of prostaglandins, leukotriene B4 and lipoxin. LB4H is an NADP-dependent enzyme. Relevance LB4H 1 restricts inflammation and confers resistance to tuberculosis infection. Structural highlights LB4H active site is located at the hydrophobic pore (Hydrophobic, Polar) on the dimer interface. Pore.

3D Structures of Leukotriene B4 hydroxydehydrogenase

1zsv – LB4H - human
2dm6 –gpLB4H/15-oxo-prostaglandin 13-reductase+indomethacin – guinea pig
1v3t, 1v3u - gpLB4H/15-oxo-prostaglandin 13-reductase
1v3v - gpLB4H/15-oxo-prostaglandin 13-reductase+NADP+15-oxo-PGE-2

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