MAP kinase phosphatase

spinqualitylabelsall models MAP kinase phosphatase 3 (PDB code 1hzm) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function MAP kinase phosphatase (MKP) or Dual specificity phosphatase (DUSP) are phosphatases which reverse the activation of MAP kinases by dephosphorylating tyrosine or threonine residues. MKP-2 is essential in protection against intracellular infection. MKP-3 is localized in the nucleus and dephosphorylates phosphoTyr in p38a. MKP-4 is localized in the nucleus and cytosole MKP-5 is localized in the nucleus and cytosole and is involved in pressure overload-induced cardiac fibrosis. MKP-6, MKP-7 are localized in the nucleus Relevance DUSP is implicated in the initiation and development of cancer.

3D Structures of MAP kinase phosphatase

Updated on 15-December-2025

3ezz – hMKP-2 (mutant) or DUSP-HVH2 - human
2hcm – mDUSP
1m3g – hMKP-PAC-1 catalytic domain (mutant) - NMR
2g6z – hMKP-3
1hzm - hMKP-3 or DUSP-5
1mkp - hMKP-3 or DUSP-5 (mutant)
3lj8 – hMKP-4
4jmk – hDUSP-8 (mutant)
2ouc, 2oud, 1zzw, 7y4c - hMKP-5 or DUSP-10
7y4b, 7y4d, 7y4e, 9bpn, 9nym, 9y55 – hMKP-5 (mutant)
6mc1, 7u4o, 7u4r, 7umu, 7umv, 7un0, 7un4 – hMKP-5 + inhibitor
9bu4, 9nsb, 9o8w, 9ok9, 9q7x – hMKP-5 (mutant) + inhibitor
3tg1 – hMKP-5 + MAP kinase 14
4jmj – hDUSP-11 catalytic domain (mutant)
2wgp – hMKP-6 or DUSP-14
1yz4 – hDUSP-15 catalytic domain (mutant)
2vsw, 3tg3 - hMKP-7 or DUSP-16
4yr8 – hMKP-7 + MAPK8
4d3p, 4d3q, 4d3r – hDUSP-19 (mutant)
4woh – hDUSP-22 (mutant) + nitrophenolphosphate
2img – hDUSP-23 + malate
5gtj, 4b04, 4hrf – hDUSP-26 catalytic domain (mutant)

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