MDM4

spinqualitylabelsall models Human MDM4 p53-binding domain (grey) complex with p53 peptide (green) (PDB entry 3dab) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function MDM4 or MDMX is a 490 amino acid protein containing a RING finger domain (residues 300-339) and a nuclear localization signal. MDM4 interacts with protein MDM2. Both of these proteins show structure similarity and contain a p53-binding domain (or SWIB domain) in their N terminal (residues 23-111). Relevance MDM4 which is a negative regulator of p53 is upregulated in human melanomas and thus is a key therapeutic target.

3D Structures of MDM4

Updated on 16-December-2025

MDM4 domains: p53-binding 24-111; zinc finger RNBP 290-335; zinc finger-RING 428-490

2cr8 – hMDM4 ZF-RNBP domain – NMR
3dab, 2mwy, 7el4 – hMDM4 p53-binding domain + p53 transactivation domain
3dac – hMDM4 p53-binding domain (mutant) + p53 transactivation domain
2n06, 2n0u, 2n0w, 2n14 – hMDM4 p53-binding domain + p53 transactivation domain – NMR
3fdo, 3jzo, 3jzp, 3jzq, 4rxz, 5uml, 7kjn – hMDM4 p53-binding domain + peptide inhibitor
5vk1 – hMDM4 p53-binding domain + stapled peptide
3lbj, 3u15, 8ia5 – hMDM4 p53-binding domain + inhibitor
3fe7, 3fea, 3eqy - hMDM4 p53-binding domain (mutant) + peptide
6q9q, 6q9s, 6q9u, 6q9w, 6q9y – hMDM4 p53-binding domain (mutant)+ inhibitor
7c3q, 7c3y, 7c44 – hMDM4 p53-binding domain + nutlin
2vyr – hMDM4 p53-binding domain + antibody
2vje, 2vjf – hMDM4 ZF-RING domain + hMDM2 residues 383-446
5mnj – hMDM4 ZF-RING domain + hMDM2 ZF-RING domain + polyubiquitin + ubiquitin-conjugating enzyme E2
7mla – hMDM4 ZF-RING domain + cyclotide - NMR
2z5s - zMDM4 p53-binding domain + p53 transactivation domain – zebrafish
2z5t - zMDM4 p53-binding domain (mutant) + p53 transactivation domain
8gjs - zMDM4 p53-binding domain + stapled peptide
4n5t, 6v4e, 6v4f, 6v4g, 6v4h - zMDM4 p53-binding domain (mutant) + stapled peptide

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