MEP cytidylyltransferase

spinqualitylabelsall models Structure of E. coli MEP cytidylyltransferase complex with CTP, Mg+2 (small light green) and Ca+2 (large green) (PDB code 1i52). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function MEP cytidylyltransferase (MEPCT) catalyzes the conversion of 2C-methyl-D-erythritol 4-phosphate and CTP to 4-(cytidine 5’-diphospho)- 2C-methyl-D-erythritol (CDP-ME) and diphosphate. MEPCT participates in isoprenoid biosynthesis in many bacteria while eukaryotes use the mevalonic acid pathway for the isoprenoed biosynthesis. IspD/IspDF is a bifunctional enzyme which catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erithritol 4-phophate and the conversion or CDP-ME2P to ME-CPP. Relevance Inhibitors of MEPCT can be used as potential antibiotics. Structural highlights The biological assembly of E. coli MEPCT is homodimer. The active site of MEPCT contains an Mg+2 ion. Water molecules shown as red spheres. Whole active site. 3D structures of MEP cytidylyltransferase MEP cytidylyltransferase 3D structures

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