MHC I 3D structures
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3D structures of MHC I
Updated on 09-December-2025
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- MHC I
- MHC I binary complex
- Human MHC I ternary complex
- 3kpn, 3kpo – hMHC I B + β-2-microglobulin + peptide
- 1a9b, 1a9e, 1b0g, 1hsa, 1hsb, 1jf1, 1jge, 1jht, 1i4f, 1k5n, 1kpr, 1i1f, 1i1y, 1i7r, 1i7t, 1i7u, 1mhe, 1n2r, 1ogt, 1qew, 1qqd, 1s7q, 1s9w, 1s9x, 1s9y, 1t1x, 1t1y, 1t1z, 1t20, 1t21, 1t22, 1tmc, 1tvb, 1tvh, 1uxs, 1uxw, 1w0v, 1w0w, 1xh3, 1xr8, 1xr9, 1ydp, 1zhk, 1zhl, 1zsd, 2a83, 2axf, 2axg, 2bck, 2bsr, 2bss, 2bst, 2cik, 2clr, 2d31, 2fyy, 2fz3, 2git, 2gt9, 2gtw, 2gtz, 2guo, 2h6p, 2hn7, 2nw3, 2rfx, 2vab, 2x4r, 2x4t, 2xpg, 3am8, 3b3i, 3b6s, 3bgm, 3bh8, 3bh9, 3bhb, 3bo8, 3bp4, 3bp7, 3bvn, 3bw9, 3bwa, 3bze, 3bzf, 3c9n, 3czf, 3d18, 3d25, 3dtx, 3dx6, 3dx8, 3dxa, 3fqn, 3fqr, 3fqt, 3fqu, 3fqw, 3fqx, 3h7b, 3hcv, 3hpj, 3kpl, 3kpm, 3kpn, 3kpo, 3kpp, 3kpq, 3kpr, 3kps, 3l3d, 3l3g, 3l3i, 3l3j, 3l3k, 3lka, 3lkn, 3lko, 3lkp, 3lkq, 3lkr, 3lks, 3ln4, 3ln5, 3lv3, 3mr9, 3mrb, 3mrc, 3mrd, 3v5h, 3v5k, 3vfr, 3vfs, 3vfv, 4jqx, 4k7f, 4l29, 4no5, 4prb, 4prd, 4pre, 4prn, 4qrq, 4qrs, 4qrt, 4wj5, 5c0d, 5c0f, 5c0j, 5d9s, 5eo0, 5eo1, 5eu4, 5hhn, 5ib3, 5meo, 5t6x, 5txs, 5vvp, 5vud, 5w67, 6amt, 6at5, 6at9, 6d29, 6d2b, 6d2r, 6d2t, 6ei2, 6g3j, 6g3k, 6ggm, 6gh1, 6gh4, 6ghn, 6h6d, 6joz, 6jp3, 6jtn, 6jto, 6jtp, 6l9n, 6nca, 6o4y, 6o4z, 6o51, 6o53, 6o9b, 6o9c, 6opd, 6ptb, 6pte, 6pyj, 6pyv, 6pyw, 6pz5, 6q3k, 6ss7, 6ss8, 6ss9, 6ssa, 6tdo, 6tdp, 6tdq, 6trn, 6uj8, 6ujo, 6ujq, 6uli, 6ulk, 6uzm, 6uzn, 6uzo, 6uzp, 6uzq, 6uzs, 6v2o, 6v2p, 6v2q, 6vb0, 6vb1, 6vb2, 6vb5, 6vb6, 6vb7, 6viu, 6vr1, 6vr5, 6y26, 6y27, 6y28, 6y29, 6y2a, 6y2b, 6z9v, 6z9w, 6z9x, 7alo, 7ciq, 7cir, 7cis, 7dyn, 7ejm, 7lgp, 7mj6, 7mj7, 7mj8, 7mj9, 7mja, 7nmd, 7ow3, 7ow4, 7p49, 7p4b, 7q98, 7re8, 7rzd, 7rzj, 7s79, 7s7d, 7s7e, 7s7f,7s8a, 7s8e, 7s8f, 7t5m, 7u21, 7wt3, 7wt4 , 7wt5, 7wzz, 7x00, 7zuc, 8dvg, 8esh, 8fu4, 8i5d, 8i5e, 8isn, 8sbk, 8sbl, 8tbv, 8tbw, 8u9g, 8xes, 8xfz, 9d97, 9l47, 9l48, 9l49, 9l4a, 9skp, 9sl0 - hMHC I + beta-2-microglobulin + peptide
- 1cg9, 1kpr, 1ktl, 1m05, 1m6o, 2av1, 2av7, 3ft2, 3ft3, 3ft4, 3gso, 3gsq, 3gsr, 3gsu, 3gsv, 3gsw, 3gsx, 3h9h, 3kww, 3kyo, 3ixa, 3vfm, 3vfo, 3x11, 3x12, 3x14, 6iwh, 7tuc, 8e13, 8e2z, 8esh - hMHC I (mutant) + β-2-microglobulin + peptide
- 6mpp - hMHC I + β-2-microglobulin + peptide – NMR
- 3i6k, 3i6l, 6iex, 7ejl, 7ejn, 7eu2, 7f4w, 7lfz, 7lg0, 7lg2, 7lg3, 7lgd, 7kgo, 7kgp, 7kgq, 7kgr, 7kgs, 7kgt, 7m8s, 7m8t, 7m8u, 7mkb, 7n1a, 7n1b, 7n6d, 7p3d, 7p3e, 7rtd, 7sa2, 7sis, 7tlt, 7u1r, 7um2, 7ur1, 7xqs, 8elg, 8elh, 8hn4, 8ht9, 8rbu, 8rbv, 8rcv, 8ref, 8rh6, 8rhq, 8xg2, 8xkc, 8xke, 8yzr, 8yzw, 8z08, 8zv9, 9f13 - hMHC I + β-2-microglobulin + SARS protein peptide
- 2x4p, 2x4q, 2x4s, 2x70, 3mgo, 3mgt, 4mj6, 4nqx, 5wxc, 5wxd, 6mtl, 6pbh, 6xqa, 7jyv, 7jyu, 7jyw, 7jyx, 7nui, 7xf3, 8emk, 8kb1, 8rng, 8rnh, 8roo, 8rop, 8tuh, 8wo9, 9dy8 - hMHC I + β-2-microglobulin + influenza A peptide
- 1a1m, 1a1n, 1a1o, 1e27, 1e28, 1hhg, 1hhh, 1hhi, 1hhj, 1hhk, 1q94, 1qvo, 1s8d, 1t1w, 2bvo, 2bvp, 2bvq, 2c7u, 2hjk, 2hjl, 2v2w, 2v2x, 2x4n, 2x4o, 2x4u, 3giv, 3vxn, 3vxo, 3wlb, 4lnr, 4u1i, 4wu5, 4wu7, 5v5l, 5xos, 6bxp, 6bxq, 6gl1, 6j1v, 6j1w, 6p23, 6p27, 6p2c, 6p2f, 6p2s, 6pyl, 6vpz, 6vq2, 6vqd, 6vqe, 6vqy, 6vqz, 7r7v, 7r7w, 7r7x, 7r7y, 7sif, 7sig, 7sih, 7wj2, 7wj3, 8e8i, 8ec5, 8f7m, 9k2t - hMHC I + β-2-microglobulin + HIV peptide
- 7n19 - hMHC I +b + β-2-microglobulin + peptide
- 1n2r, 1syv - hMHC I + β-2-microglobulin + hMHC II peptide
- 4emz - hMHC I + NEF + peptide
- 9ru5 - hMHC I + TCR + peptide – Cryo EM
- 4nqe, 4pjc, 7lli - hMHC I + β-2-microglobulin + TCR
- 4pj9 - hMHC I (mutant) + β-2-microglobulin + TCR
- 8esb - hMHC I /β-2-microglobulin/peptide – Cryo EM
- 3kpn, 3kpo – hMHC I B + β-2-microglobulin + peptide
- Non-human MHC I ternary complex
- 4zus - hoMHC I + β-2-microglobulin + peptide – horse
- 3pwv - MHC I + β-2-microglobulin + peptide – bovine
- 3jts, 6hwj - rmMHC I + β-2-microglobulin + peptide – Rhesus macaque
- 6lah, 6lam, 6lb2, 6lt6 - rmMHC I (mutant) + β-2-microglobulin + lysophospholipid
- 3qq3, 3qq4, 5h94, 5nq1, 6a6h, 6kwk, 6kwl, 6kwo, 6lf8, 6lf9, 7em9, 7ema, 7emb, 7emc, 7emd, 8gqv, 8gqw, 9ul1 - pMHC I + β-2-microglobulin + peptide – pig
- 6kwn - pMHC I (mutant) + β-2-microglobulin + peptide
- 1kjv, 1kjm, 1ed3 – MHC I + β-2-microglobulin + peptide - rat
- 2oi9 - mMHC I + T cell receptor + peptide
- 1bz9, 1ffn, 1ffo, 1ffp, 1fg2, 1g7p, 1g7q, 1hoc, 1juf, 1jpf, 1jpg, 1k8d, 1kbg, 1kpu, 1kpv, 1inq, 1ld9, 1lek, 1leg, 1lk2, 1n3n, 1n59, 1n5a, 1nan, 1qlf, 1rjy, 1rjz, 1rk0, 1rk1, 1s7q, 1s7r, 1s7s, 1s7t, 1s7u, 1s7v, 1s7w, 1s7x, 1t0m, 1t0n, 1vac, 1vad, 1vgk, 1wbx, 1wby, 1wbz, 1yn6, 1yn7, 1zhb, 1zt1, 1zt7, 2cii, 2e7l, 2f74, 2ffo, 2mha, 2ve6, 2zok, 2zol, 2zsv, 2zsw, 3buy, 3cc5, 3cch, 3ch1, 3cpl, 3e6f, 3ecb, 3ftg, 3fol, 3l3h, 3quk, 3qul, 3rol, 3roo, 3tbs, 3tbt, 3tbv, 3tbw, 3tid, 3tie, 3tby, 4nsk, 4pg9, 4pgd, 4pge, 5j6h, 5opi, 5ts1, 6g9r, 6gb5, 6gb6, 6gb7, 6jq2, 6jq3, 6npr, 6x00, 7ji2, 7lfi, 7n5q, 8d5j - mMHC I + β-2-microglobulin + peptide
- 2qri - mMHC I/β-2-microglobulin/peptide
- 2qrs, 2qrt - mMHC I (mutant)/β-2-microglobulin/peptide
- 1ddh, 1fzj, 1fzk, 1fzm, 1fzo, 1mhc, 2clv, 2clz, 7lfj - mMHC I (mutant) + β-2-microglobulin + peptide
- 6bga, 6wl2, 6wl3, 6wl4 - mMHC I + T cell receptor + peptide
- 3e2h, 3e3q - mMHC I (mutant) + T cell receptor + peptide
- 1nez - mMHC I + β-2-microglobulin + CD8 chain
- 7dc6 – MHC I + β-2-microglobulin + peptide – panda
- 5f1n, 7cjq – MHC I + β-2-microglobulin + peptide – dog
- 6m24, 6m2j, 6m2k – MHC I + β-2-microglobulin + peptide – rabbit
- 7edo – MHC I + β-2-microglobulin + peptide – possum
- 6a2b – MHC I + β-2-microglobulin + peptide – frog
- 6j2d, 6j2e, 6j2g, 6j2h, 6j2i, 6j2j, 6k7t – MHC I + β-2-microglobulin + peptide – bat
- 7cpo – MHC I + β-2-microglobulin + peptide – Anolis carolinensis
- 6ilc, 6ile, 6ilf, 6ilg – MHC I + β-2-microglobulin + peptide – flying fox
- 2yez, 3bev, 3bew, 3rwc, 3rwd, 3rwe, 3rwf, 3rwg, 3rwh, 3rwi, 3rwj, 4cvx, 4cvz, 4d0b, 4d0c, 4d0d, 4cw1, 4zfz, 5ad0, 6iwg, 6irl, 6kx9, 6lhf, 6lhg, 6lhh, 7wbg, 7wbi, 8z0h – cMHC I + β-2-microglobulin + peptide
- 4e0r, 4g42 – cMHC I (mutant) + β-2-microglobulin + peptide
- 7zqj, 7zqi – MHC I + β-2-microglobulin + peptide – warbler
- 6kyu – MHC I + β-2-microglobulin + peptide – duck
- 5h5z, 6lbe – MHC I + β-2-microglobulin + peptide – bony fish
- 6lup – MHC I +β -2-microglobulin + peptide – shark
- 4zus - hoMHC I + β-2-microglobulin + peptide – horse
- MHC I quaternary complex
- 1lp9, 1oga, 1qrn, 2bnq, 2bnr, 2esv, 2f53, 2f54, 2gj6, 2j8u, 2p5e, 2p5w, 2pye, 3d39, 3d3v, 3ffc, 3gsn, 3h9s, 3mv7, 3mv9, 3o4l, 3qdg, 3qdj, 3qdm, 3qeq, 4eup, 4ftv, 4jfd, 4jry, 4pri, 4qrp, 5brz, 5c08, 5e9d, 5wkh, 6amu, 6avf, 6avg, 6bj8, 6d78, 6dkp, 6eqa, 6eqb, 6g9q, 6pue, 6puf, 6pug, 6pui, 6puj, 6puk, 6pul, 6pum, 6pvc, 6pvd, 6px6, 6q3s, 6r2l, 6rsy, 6tmo, 6tro, 6uk2, 6uk4, 6uln, 6ulr, 6uon, 6uz1, 6vm7, 6vm8, 6vm9, 6vqo, 6vma, 6vmc, 6vmx, 6vrm, 6vrn, 6zky, 7lfk, 7lfl, 7lfm, 7ndt, 7nme, 7nmf, 7nmg, 7ow5, 7ow6, 7pb2, 7q99, 7q9a, 7q9b, 7qpj, 7rk7, 7rrg, 7su9, 8cx4, 8i5c, 8qfy, 8rlu, 8rlv, 8rro, 8rym, 8ryn, 8ryo, 8ryp, 8ryq, 8shi, 8wte, 8wul, 9d95, 9gv6, 9hi7 - hMHC I + T cell receptor + beta-2-microglobulin + peptide
- 2jcc, 2uwe, 3kxf, 3mv8 - hMHC I (mutant) + T cell receptor + β-2-microglobulin + peptide
- 7n1e, 7n1f, 7n6e, 7pbe, 7rtr, 8dnt, 8gom, 8gon, 8rj5, 8rji, 9j4u - hMHC I + T cell receptor + β-2-microglobulin + SARS peptide
- 2vlj, 2vlk, 2vll, 2vlr, 6mt3, 6mt4, 6mt5, 6mt6, 6mtm, 7n4k, 7n5c, 7n5p, 7n5q, 8en8, 8enh - hMHC I + T cell receptor + β-2-microglobulin + influenza A peptide
- 3vxm, 3vxs, 4mji, 5nmf, 6bj2, 6bj3, 7dzm, 7dzn, 7r80, 8f5a, 8gvb, 8gvg, 8gvi, 9k2r - hMHC I + T cell receptor + β-2-microglobulin + HIV peptide
- 9o06, 9o07 - hMHC I + T cell receptor + β-2-microglobulin + flavin derivative
- 9bys - hMHC I + T cell receptor + β-2-microglobulin + ribitol derivative
- 7phr, 8es8, 8es9 - hMHC I + T cell receptor + β-2-microglobulin + peptide + CD3 – Cryo EM
- 1im9, 1p7q, 6ewc - hMHC I + leukocyte immunoglobulin-like receptor + β-2-microglobulin + peptide
- 5t6z, 6v3j, 7k80, 7k81, 9bl2, 9bl3, 9bl4, 9bl5, 9bl6, 9bl9, 9bla, 9d96 - hMHC I + KIR3DL1 + β-2-microglobulin + influenza A peptide
- 6pa1 - hMHC I + KIR2DL2 + β-2-microglobulin + influenza A peptide
- 6pag - hMHC I + KIR2DL3 + β-2-microglobulin + influenza A peptide
- 6aee, 6k60 - hMHC I + LIR-1 + β-2-microglobulin + peptide
- 6ewo - hMHC I + LIR-1 + synemin + β-2-microglobulin + peptide
- 6ewa - hMHC I + LIR-1 + polyprotein + β-2-microglobulin
- 7qng - hMHC I + protein disulfide isomerase + tapasin + β-2-microglobulin
- 6eny, 7qpd - hMHC I + calreticulin + protein disulfide isomerase + tapasin + -2-microglobulin – Cryo EM
- 2dyp - hMHC I (mutant) + leukocyte immunoglobulin-like receptor +β -2-microglobulin + peptide
- 1akj, 1bqh, 3dmm, 3qzw - hMHC I + β-2-microglobulin + CD8 + peptide
- 1im3 - hMHC I + β-2-microglobulin + cytomegalovirus protein US2 + peptide
- 3cdg, 3cii - hMHC I + β-2-microglobulin + CD94 ectodomain + NKG2A/NKG2B integral membrane protein + peptide
- 1w72, 3cvh, 3gjf, 3hae, 5d2n, 6id4, 6uj9, 6w51, 7bbg, 7bh8, 7re7, 8eb2, 8fja, 8fjb, 8t7r, 8tnj, 9pix, 9pkf - hMHC I + β-2-microglobulin + antibody + peptide
- 7t0l - hMHC I (mutant) + β-2-microglobulin + antibody + peptide
- 9pkv - hMHC I + β-2-microglobulin + antibody + Vhh + peptide – Cryo EM
- 7sr3, 7sr5, 7srk - hMHC I /β-2-microglobulin/peptide + Vhh
- 8ek5 - hMHC I + β-2-microglobulin + peptide + scFv
- 7duu - hMHC I + β-2-microglobulin + KIR receptor + peptide
- 4e5x - hMHC I + β-2-microglobulin + E3-19K + peptide
- 9rcv - hMHC I in peptide-loading complex – Cryo EM
- 7byd - rmMHC I + β-2-microglobulin + TCR + peptide
- 1fo0, 1g6r, 1mwa, 1nam, 2ckb, 2z31, 3pqy, 7jwi - mMHC I + T cell receptor + β-2-microglobulin + peptide
- 2oi9 - mMHC I (mutant) + T cell receptor + β-2-microglobulin + peptide
- 1p1z, 1p4l, 1qo3, 5j6g - mMHC I + β-2-microglobulin + natural killer cell receptor LY49C + peptide
- 3c8k - mMHC I (mutant) + β-2-microglobulin + natural killer cell receptor LY49C + peptide
- 1lp9, 1oga, 1qrn, 2bnq, 2bnr, 2esv, 2f53, 2f54, 2gj6, 2j8u, 2p5e, 2p5w, 2pye, 3d39, 3d3v, 3ffc, 3gsn, 3h9s, 3mv7, 3mv9, 3o4l, 3qdg, 3qdj, 3qdm, 3qeq, 4eup, 4ftv, 4jfd, 4jry, 4pri, 4qrp, 5brz, 5c08, 5e9d, 5wkh, 6amu, 6avf, 6avg, 6bj8, 6d78, 6dkp, 6eqa, 6eqb, 6g9q, 6pue, 6puf, 6pug, 6pui, 6puj, 6puk, 6pul, 6pum, 6pvc, 6pvd, 6px6, 6q3s, 6r2l, 6rsy, 6tmo, 6tro, 6uk2, 6uk4, 6uln, 6ulr, 6uon, 6uz1, 6vm7, 6vm8, 6vm9, 6vqo, 6vma, 6vmc, 6vmx, 6vrm, 6vrn, 6zky, 7lfk, 7lfl, 7lfm, 7ndt, 7nme, 7nmf, 7nmg, 7ow5, 7ow6, 7pb2, 7q99, 7q9a, 7q9b, 7qpj, 7rk7, 7rrg, 7su9, 8cx4, 8i5c, 8qfy, 8rlu, 8rlv, 8rro, 8rym, 8ryn, 8ryo, 8ryp, 8ryq, 8shi, 8wte, 8wul, 9d95, 9gv6, 9hi7 - hMHC I + T cell receptor + beta-2-microglobulin + peptide
- MHC I in single chain trimer chimera
