7,8-dihydro-8-oxoguanine triphosphatase

spinqualitylabelsall models Structure of human MTH1 complex with 8-oxo-dGTP and sulfate (PDB code 3zr0). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function 7,8-dihydro-8-oxoguanine triphosphatase (DGTP) converts 8-oxoguanine containing deoxyribonucleoside triphosphate to the corresponding monophosphate. DGTP controls spontaneous mutagenesis caused by exogenous oxygen radicals. The E. coli DGTP is called MutT. The human DGTP is called MTH1. For details on MTH1 see Student Project 7 for UMass Chemistry 423 Spring 2015. Relevance The 8-oxo-dGTP (oxoG) is a potentially mutagenic substrate when incorporated into DNA. Structural highlights Active site of DGTP (PDB code 3zr0). Water molecules are shown as red spheres. 8-oxo-dGTP is located in the tunnel. 3D structures of 7,8-dihydro-8-oxoguanine triphosphatase 7,8-dihydro-8-oxoguanine triphosphatase 3D structures

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