Malate synthase

spinqualitylabelsall models Structure of malate synthase G complex with CoA, malate, Hepes and Mg+2 ion (green) (PDB entry 2gq3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Malate synthase (MS) catalyzes the reversible conversion of acetyl-CoA, glyoxylate and water to (S)-malate and CoA. MS participates in pyruvate, glyoxylate and dicarboxylate metabolism. There are 2 isozymes of MS. MS G is formed during growth on glycolate and MS A which metabolizes glyoxylate formed in the dissimilation of acetate. See also: Glyoxylate cycle Structural highlights MS active site pocket is situated between the TIM barrel and the C-terminal. The ternary complex contains malate, acetyl-CoA and Mg+2 ion. Malate/Mg+2 ion binding site. Water molecules are shown as red spheres. Acetyl-CoA binding site. 3d structures of malate synthase Malate synthase 3D structures

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