Methyl CpG binding protein

spinqualitylabelsall models Structure of mouse MBD4 glycosylate domain complex with DNA containing mismatch, ethylene glycol and Ni+2 ion (green) (PDB code 4evv). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Methyl CpG binding proteins are called MBD1 to MBD4 and contain a methyl-CpG binding domain (MBD) which binds to methylated DNA. • MBD1 is a transcription regulator. It reverts methylated cytosine bases to cytosine. • MBD2 is part of the MeCP1 complex which contains also NuRD. MBD2 recruits histone deacetylases and DNA methyltransferases. MBD2 functions as a scaffold protein promoting repression. • MBD3 binds to hydroxymethylated DNA. • MBD4 has a G:T mispair-specific activity. • Methyl CpG binding protein 2 (MeCP2) is present in mature nerve cells and is involved in turning off several genes. For more details see Methyl CpG Binding Protein 2 and Rett Syndrome Protein. Disease Mutations in MBD2 are involved in Rett syndrome. Relevance MBD1 has a role in lung, prostate, pancreatic, colorectal cancers and promyelocytic leukemia. MBD2 has a role in lung, prostate, renal, colorectal cancers. MBD3 has a role in lung, prostate, ovarian cancers and promyelocytic leukemia. MBD4 has a role in gastric, liver and colorectal cancers. Structural highlights Thymine from the mismatched G:T pair flips out from the DNA strand and interchelates with MBD4 residues Lys and Leu. 3D structures of methyl CpG binding protein Methyl CpG binding protein 3D structures

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