Melanoma-associated antigen

spinqualitylabelsall models Human MAGEA4 MAGE homology domain (grey) complex with peptide inhibitor (green), ethanediol, ethylene glycol and TRIS (PDB id 7uoa) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Melanoma-associated antigen (MAGE) are produced by tumor cells and are recognized by cytotoxic T lymphocytes. Many such antigens have been identified and are classified into 2 groups with group I called cancer/testis antigens. The loss of MAGE expression is observed in primary melanoma. Relevance The expression of MAGE-A1 can be a marker for the prediction of resistance to taxan-based chemotherapy in pations with gastric cancer. Assessment of MAGE may provide stratification factor for active-specific immunotherapy. Structural highlights The 3D structure of the complex between MAGE-A4 and the peptide inhibitor shows the peptide to bind in a cyclic conformation. The peptide is anchored by 3 of its residues interacting with MAGE hydrophobic pocket. MAGE residue M161 makes Met-aromatic interactions with 2 of the peptide Tyr residues. Additional H-bonds are formed between the peptide inhibitor and MAGE. 3D structures of melanoma-associated antigen Updated on 18-December-2025 MAGE; Domains: MAGE homology 101-317; PWWP 405-538 3pmi – hMAGE1 PWWP domain (mutant) – human 4v0p – hMAGEA3 MAGE homology domain 9bd2 – hMAGEA3 MAGE homology domain + KL861 8t9a – hMAGEA3 MAGE homology domain + DDB1-DCAF12 – Cryo EM 2wa0 – hMAGEA4 MAGE homology domain 7uoa – hMAGEA4 MAGE homology domain + peptide inhibitor 6r7t – hMAGEB1 MAGE homology domain + nanobody 5hvq, 5wy5 – hMAGEG1 MAGE homology domain + NSE-1 6xr0 – hMAGEP97 + antibody

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky