Methylcitrate synthase

spinqualitylabelsall models Methylcitrate synthase dimer complex with glycerol (PDB entry 3o8j) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Methylcitrate synthase (MCS) participates in propanoate metabolism. It catalyzes the conversion of acyl to alkyl group in the reaction which converts propanoyl-CoA and oxaloacetate to 2-hydroxybutane-1,2,3-tricarboxylate and CoA. The metabolism of propionyl-CoA in microorganism is performed by the methylcitrate cycle. The methylcitrate cycle contains MCS, methylcitrate dehydrogenase and methylisocitrate lyase. The methylcitrate cycle can serve as a carbon and energy source of growth. In the presence of glucose, the cycle serves to remove the toxic propionate. Relevance The high levels of propionate used to preserve foodstuffs lead to fungal growth inhibition via the accumulation of intermediates of the methylcitrate cycle. See also Citrate Synthase.

3D structures of methylcitrate synthase

Updated on 02-November-2021

Citrate Synthase – MCS – Mycobacterium tuberculosis
3o8j – MCS – Salmonella enterica
3tqg – MCS – Coxiella burnetii
5uqo, 5uqq, 5uqr – Af2-MCS – Aspergillus fumigata
5uqu, 6bom, 6bop – Af2-MCS (mutant)
6bol – Af2-MCS (mutant) + oxaloacetate
6bon, 6boo – Af2-MCS + oxaloacetate + CoA
6s6f – Pa2-MCS – Pseudomonas aeruginosa
6s87 – Pa2-MCS + oxaloacetate

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