Mineralocorticoids

spinqualitylabelsall models Glycosylated human mineralocorticoid receptor ligand-binding domain complex with aldosterone, glycerol and sulfate (PDB entry 2aa2) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Mineralocorticoids are a class of corticosteroids. Mineralocorticoids are produced in the adrenal cortex and influence salt and water balances (electrolyte balance and fluid balance). The primary mineralocorticoid is aldosterone. Mineralocorticoid receptor (MR) in epithelial cells is activated by the mineralocorticoid hormone aldosterone promoting renal sodium retention and potassium excretion. It is nuclear receptor. In non epithelial cells MR is activated by cortisol. MR is exposed to many steroids including cortisol, cortisone and progesterone, however, aldosterone and deoxycorticosterone are its physiological ligands. MR mutations are the principal cause of renal pseudohypoaldosteronism. MR mutation S810L causes early-onset hypertension. Inhibition of cardia MR prevents doxorubicin-induced cardiotoxicity. MR is an important proadipogenic transcription factor that may mediate aldosterone and glucocorticoid effects on adipose tissue development and hence on obesity and development of metabolic syndrome. The MR ligand aldosterone binds in a fully enclosed pocket, contacting residues with six α-helices and a β-turn (Alpha Helices, Beta Strands , Loops ,Turns). It forms hydrogen bonds with 4 MR residues. Whole binding site. Water molecules are shown as red spheres. Angiotensin-Converting Enzyme, Renin-Angiotensin-Aldosterone System. Corticosteroid-binding globulin Hydroxysteroid dehydrogenase

See also:

• Mineralocorticoid receptor

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Alexander Berchansky