Monoamine oxidase

spinqualitylabelsall models Human MAO-B complex with safinamide and FAD (PDB entry 2v5z) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Monoamine oxidase or amine oxidase (Flavin-containing) (MAO) are enzymes which catalyze the oxidation of monoamines. MAO contains FAD as co-factor. MAO-A and MAO-C are human enzymes which oxidize adrenaline, noradrenaline, serotonin and dopamine. MAO-B or amine oxidase [flavin-containing] B is a human enzyme which oxidizes benzylamine and phenylethylamine. For details on MAO-B see Monoamine oxidase b. MAO-N is a Aspergillus niger enzyme which oxidizes primary amines. Relevance Elevated levels of MAO-A in the brain are measured during depression. MAO inhibitors were the first anti-depression drugs developed. Structural highlights MAO-B active site is composed of 2 cavities: the substrate cavity in front of the FAD and the entrance cavity. Safinamide - a drug tested for Parkinson's disease - occupies both cavities. Whole active site. Water molecules are shown as red spheres. Safinamide binding site.

3D structures of monoamine oxidase

Updated on 29-December-2025

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• MAO-A
  • Monoamine oxidase b, 2bxr, 2bxs – hMAO-A + inhibitor + FAD – human
    
  • 2z5y - hMAO-A (mutant) + inhibitor + FAD
    
  • 1o5w - MAO-A + inhibitor + FAD – rat
    
  • 8eei - CaMAO-A + FAD – Corynebacterium ammoniagenes
    
  • 8een - CaMAO-A (mutant) + FAD
    
  • 8eef, 8eeg, 8eeh, 8eek, 8eel, 8eem, 8eeo - CaMAO-A + FAD + amine
    
  • 8eej - CaMAO-A (mutant) + FAD + amine
    
• MAO-B
  • 1gos – hMAO-B
    
  • 1oj9, 1oja, 1ojc, 1ojd, 1s2q, 1s2y, 1s3b, 1s3e, 2byb, 2bk3, 2c64, 2c65, 2c66, 2c67, 2vz2, 2vrl, 2vrm, 2v5z, 2v60, 2v61, 2xcg, 2xfn, 2xfp, 2xfq, 2xfu,3po7, 4a7a. 4crt, 5mrl, 6fvz, 6gw0, 6fwc, 6fw0, 6rkb, 6rkp, 6rle, 6yt2, 7b0v, 7b0z, 7p4f, 7p4h, 7zw3, 9fjt, 9r2j, 9r3j, 9r3k – hMAO-B + inhibitor + FAD
    
  • 2xfo, 2bk4, 2bk5 - hMAO-B (mutant) + inhibitor + FAD
    
  • 2c72, 2c73, 2c75, 2c76 - hMAO-B (mutant) + FAD
    
  • 2c70 - hMAO-B + FAD
    
  • 3zyx - hMAO-B + methylene blue + FAD
• MAO-C
  • 3qj4 – hMAO-C + FAD
• MAO-N
  • 2vvl, 2vvm, 3zdn – MAO-N (mutant) + FAD – Aspergillus niger
• MAO
  • 8p84 - TbMAO + FAD – Thermoanaerobacterales bacterium
    
  • 9h5p, 9h5q, 9h5z, 9h64 - TbMAO + FAD + amine
    

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