Myeloperoxidase

spinqualitylabelsall models Dog glycosylated myeloperoxidase dimer: heavy chain (pink and yellow), light chain (grey and green) containing heme complex with Ca+2 ions (green) (PDB entry 1myp) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Myeloperoxidase (MPO) catalyzes the production of HOCl from hydrogen peroxide and chloride ion during the neutrophil respiratory burst. The hypochlorous acid is used by the neutrophil to kill bacteria and other pathogens. MPO is a dimer consisting of 2 light chains and two variable-length heavy chains. MPO has a heme pigment which causes its green color in secretions like mucus which are rich in neutrophils. Relevance MPO inhibitors are tested as therapeutic drugs in a number of kidney, inflammatory, cardiovascular, neurodegenerative and immune-mediated diseases. Disease MPO is an important pathogenic factor in glomerular and tubulointestitial diseases. MPO polymorphism is associated with increased risk of Alzheimer's disease.

3D structures of myeloperoxidase

Updated on 24-March-2026

1cxp, 1mhl – hMPO C – human
3f9p, 5fiw, 5mfa, 7oih - hMPO
1d2v – hMPO C + Br
1d5l – hMPO + CN
1d7w - hMPO + CN + Br
1dnu - hMPO + SCN
1dnw - hMPO + CN + SCN
3zs0, 3zs1, 4c1m, 5uzu, 5wdj, 5qj2, 5qj3, 6wxz, 6wy0, 6wy5, 6wy7, 6wyd, 7lae, 7lag, 7lal, 7lan, 7ni1, 7ni3 - hMPO + inhibitor
4dl1 - hMPO + thioxanthine
4ejx - hMPO + ceruplasmin
6azp, 6bmt, 7qzr, 7z53 - hMPO + staphylococcal peroxidase inhibitor
1myp – MPO – dog
1qo4 - MPO – Arabidopsis thaliana

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky