Myomesin

spinqualitylabelsall models Human myomesin-1 immunoglobulin-like domains 9-11 (PDB code 2y23) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Myomesin or Skelemin is expressed in striated muscle cells. It contains type-III fibronectin (motif I) and C2-immunoglobulin (motif II) domains. Myomesin is found in the M-bridges of sarcomeres which produce the muscle contraction and provide their elasticity. The giant protein Titin interconnects the major structure of sarcomeres - the M bands and Z discs. The C-terminal of titin binds to myomesin-1 and myomesin-2. Myomesin-1 and myomesin-2 have a unique N-terminal region followed by 12 motifs in the order of II-II-I-I-I-I-I-II-II-II-II-II. Relevance The up-regulation of myimesin denotes an adaptive remodeling of the sarcomere cytoskeleton in dilated heart and mya serve as a marker for dilated cardiomyopathy. Structural highlights The structure of myomesin-1 domains 9-11 show a superhelical coil arrangement which can be stretched to about 2.5-fold of its original length by reversible unfolding of the linkers. This property of the protein can explains its role in the elasticity of muscle fibers.

3D structures of myomesin

Updated on 14-November-2021

Titin, 5fm8 - hMyo-1 domain 4 510-618 - human
6zva - hMyo-1 domain 5 632-735
5fm5 - hMyo-1 domains 4-5 + obscurin-like-1
2y23 - hMyo-1 domains 9-11 1141-1447
6t3o - hMyo-1 domain 10 1247-1357
2r15 - hMyo-1 domains 12-13 1225-1443
3rbs - hMyo-1 domains 10-11 1247-1447
4v10 - hMyo-1 domains 12-13 1225-1443 (mutant)
2jtd - hMyo-1 1207-1328 - NMR
2y25 - hMyo-1 domains 11-13 1357-1667

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Michal Harel