NAD(P) transhydrogenase

spinqualitylabelsall models Structure of PTH domains I (cyan and green) and III (pink) complex with NAD, NADP and glycerol (PDB entry 1u2d) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D NAD(P) transhydrogenase (PTH) catalyzes the conversion of NADP and NADH to NADPH and NAD. See NAD and NAD(P)H. The reaction is coupled with proton translocation across the cell membrane while the enzyme undergoes conformational change. PTH uses FAD as cofactor. Structural highlights PTH is composed of 3 domains: Domain I binds NAD(+)/NADH. Domain II is a membrane-spanning domain. Domain III binds NADP(+)/NADPH. PTH is composed of 2 subunits. Subunit β contains domain III and part of II. The active site of PTH contains NAD in domain I and NADP in domain III. Water molecules are shown as red spheres. 3D structures of NAD(P) transhydrogenase NAD(P) transhydrogenase 3D structures

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