NADP-dependent malic enzyme

<StructureSection load='3wja' size='340' side='right' caption='The best structure for NADP-dependent malic enzyme shown: 3wja' scene=> Best example is PDB entry 3wja and is shown in the viewer.

Catalytic Activity

Oxaloacetate = pyruvate + CO(2).Data source: Uniprot P48163
Or the decarboxylation of malate to pyruvate.

Biological process

Is involved in the following biological processes:
malate metabolic process
oxidation-reduction process
response to carbohydrate
response to hormone
carbohydrate metabolic process
protein tetramerization
regulation of NADP metabolic process
NADP biosynthetic process
small molecule metabolic process
cellular lipid metabolic process

In structures

NADP-dependent malic enzyme is found in 3 PDB entries

• Eukaryota (3 PDB entries):
  
  • Homo sapiens (2 PDB entries):
    
    • 3wja
    • Title: The crystal structure of human cytosolic NADP(+)-dependent malic enzyme in apo form
    • 2.548 A resolution
    • Search the PDB for NADP-dependent malic enzyme from Homo sapiens
  • Columba livia (1 PDB entries):
    
    • 1gq2
    • Title: MALIC ENZYME FROM PIGEON LIVER
    • 2.5 A resolution

Alternative names for NADP-dependent malic enzyme

Molecule NADP-dependent malic enzyme, also known as NADP-ME, NADP-dependent malic enzyme and Malic enzyme 1.

3D Structures of NADP-dependent malic enzyme

Updated on 24-March-2026

3wja, 2aw5 – hME - human
7x11, 7x12 – hME1 + NADP
8e76, 8eyn – hME3
8e78, 8e8o, 8eyo – hME3 + NADP
1gq2 – ME + NADP - pigeon
5ou5 – maME 62-636 - maize
9e6m – maME 62-636 (mutant) + pyruvate
9ks0 – EcME PTA domain 429-759 – Eschericia coli
8jzo, 9krw – EcME – Cryo EM
9m2i – EcME ME domain 1-440 – Cryo EM
9krt – EcME + NADP – Cryo EM
9m35 – EcME ME domain + NADP – Cryo EM
9l4n – EcME + acetyl CoA + NADP - Cryo EM
9kru – BbME + NADP – Bdellovibrio bacteriovorus - Cryo EM
9krv – BbME + acetyl CoA + NADP - Cryo EM

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PDBe, Michal Harel, Jaime Prilusky